Protein Alignment nAChRbeta2 and chrna4

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_031749826.1
• Gene: chrna4 / 100135106
• XenbaseID: XB-GENE-5994598
• Length: 762
• Species: Xenopus tropicalis
• Alignment Length: 595
• Identity: 213/595 - (35%)
• Similarity: 306/595 - (51%)
• Gaps: 159/595 - (26%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            :||...|.|.||:..|||.|.::.:.|..||.::|||:|:.|||:||||:||||.|.||||||||
 Frog   171 ERLLKGLFSGYNKWSRPVANISDAVMVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP 235

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEY 160
            .||..|..:.:|||.||.||||||||.||::.||.:|||.|.:.|.:.|.|||||||||.::|.:
 Frog   236 LEYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRIKWTPPAIYKSSCSIDVTF 300

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDL----KHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKN 221
            ||:|:|.|.||||||||:.|::||    .|:||:             :::.|.||.|:......|
 Frog   301 FPFDQQNCTMKFGSWTYDRAKIDLISMHSHVDQL-------------DYWESGEWVIVNAVGNYN 352

  Fly   222 EEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVS 286
            .:.|....|.:||||:...:||..||||:|||:||:.::.||||||||||:.|||:|||||:|:|
 Frog   353 IKKYECCTEIYSDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLS 417

  Fly   287 LTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFL 351
            ||||.||:.||||.|||.:||:|:|||||||.|:||:..||.|||:|.|||.||.|...||:.||
 Frog   418 LTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRTHTMPAWVRRTFL 482

  Fly   352 HFMPKLMMMRR------------------------------------TQYTLPDYDDSTPSNGYT 380
            ..:|:::.|:|                                    :....|.....:|::...
 Frog   483 DVVPRVLFMKRPAKDNCKKLIESLHARSFNPPPRLWSEAEIEPAFASSSSASPTSQRPSPTSSCC 547

  Fly   381 NEID--------------------VRDSISDFPSEF----------------------------K 397
            ::::                    ...:::..||..                            |
 Frog   548 HQLEQSPNAQVFCKSPSGQYSMLCEESALTSCPSPKPETKLLSEAQPNLMPKVRSVSVQQMYTPK 612

  Fly   398 DSQDGAY--------------DNGMQNSVDSDNVI---------------------PRN------ 421
            ::.:||.              |....|...|.:.:                     |::
 Frog   613 EANEGAVRCRSRSIQYCFLHEDFSQANGQASSSPVAQKGNGNEPQPSSHTSPCTCKPKSQEKPVD 677

  Fly   422 -----------------LTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFT 469
                             ::|.:..|:..|.:||.|::..|.|..:.:|||:|:||:||.|||:|.
 Frog   678 PSQGAKTVNAKEHHVLLMSPSLKLAIEGVHYIADHLRAEDADFSVKQDWKYVAMVIDRIFLWMFI 742

  Fly   470 LSCVFGTLAI 479
            :.|:.||:.:
 Frog   743 IVCLLGTVGL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	213/593 (36%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	105/219 (48%)
chrna4	XP_031749826.1	LGIC_ECD	170..376	CDD:355788	105/217 (48%)
		Neur_chan_memb	383..753	CDD:397193	103/370 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1443
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9533
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060