Protein Alignment nAChRbeta2 and chrnb1

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001240739.1
• Gene: chrnb1 / 100006941
• ZFINID: ZDB-GENE-070821-4
• Length: 492
• Species: Danio rerio
• Alignment Length: 464
• Identity: 185/464 - (39%)
• Similarity: 273/464 - (58%)
• Gaps: 30/464 - (6%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPE 96
            :|...|.|.||..:||..|..|.:.|.:|:.||..:.:|:|::.|.|.:.:...|.||:|.|:|:
Zfish    28 KLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEEMNTIVMMNLEWNDYRLSWNPK 92

  Fly    97 EYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYF 161
            :||||:.|.:.|..:|:|||||.||.||.:.|.|.........|.|.|.|||:|||||.:.|.||
Zfish    93 DYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAYSNGRVTWTPPALYKSSCGVKVTYF 157

  Fly   162 PYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKN--EEY 224
            |:|.|.|.|.|.|:||:.::|||:|.....|..:.::.:| |.|..|.||.|....:.||  |:.
Zfish   158 PFDWQNCTMVFRSYTYDSSEVDLQHALDKRGKEIKEIILD-TGFSESGEWHIRHKVSRKNVREDL 221

  Fly   225 YPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTV 289
            |       .||||.|.:.||.:||.||:::||:.:|.:.:..||||.|:|||:.|.|::|::|||
Zfish   222 Y-------EDITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPPDAGEKMGLSINVLLTLTV 279

  Fly   290 FFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFM 354
            |.||||..||.|||.||::..||:.|||||:.||..:|.|||:|.|||:||.|...|||:|:|.:
Zfish   280 FLLLLANKIPETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRSPNTHQMPLWVRKIFIHML 344

  Fly   355 PKLMMMRRTQYTLPDY-------DDSTPSNGYTNEIDVRDSISD---FPSEFKDSQDGAYDNGMQ 409
            |..:.|.|.:...|.:       ::....|...:|..:|...:.   ||...:...||...: ::
Zfish   345 PPYLGMLRPKVETPLFLEKPAKKENIQAINRVADEYFIRKPSNMNFLFPKPHRYQPDGQCTD-LR 408

  Fly   410 NSVDSDNVIPRN---LTPEVLQALRAVRFIAQHIKDADKDNE-IVEDWKFVSMVLDRFFLWLFTL 470
            ..:|.    |.:   |.||:..|:.|:.:||:.:: |:||.| :.|||::|:||.||.|||:|.:
Zfish   409 KFIDG----PSHYLTLPPELKTAVEAITYIAEQLQ-AEKDYEALKEDWQYVAMVADRLFLWIFVI 468

  Fly   471 SCVFGTLAI 479
            ....|||.|
Zfish   469 FTTLGTLGI 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	184/462 (40%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	87/216 (40%)
chrnb1	NP_001240739.1	LIC	6..479	CDD:273305	185/464 (40%)
		Neur_chan_LBD	26..235	CDD:280998	86/214 (40%)
		Neur_chan_memb	242..478	CDD:280999	94/242 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810