Protein Alignment nAChRbeta2 and chrnb1l

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001233249.1
• Gene: chrnb1l / 100005295
• ZFINID: ZDB-GENE-060811-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 483
• Identity: 188/483 - (38%)
• Similarity: 291/483 - (60%)
• Gaps: 24/483 - (4%)

  Fly    23 SFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWF 87
            |.:|:...:||.:||..:||..:||.....|.:.|.:|:.|.|||.:|.||..||||:::...|.
Zfish    13 SRKASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNMEWT 77

  Fly    88 DYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKS 152
            ||:|.|:||:|..::.:.:|...:|.|||.|.||.||.::|.|.....::..|.|.|.|||||:|
Zfish    78 DYRLSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAIYRS 142

  Fly   153 SCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKH-LDQIPGSNLVQVGIDLTEFYLSVEWDILEV 216
            ||.:.|.|||:|.|.|.|.|.|:||:.::|||:: ||: .|:.|.::.||...|..:.||.|...
Zfish   143 SCSIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQYGLDE-DGNELHEIVIDENAFTENGEWQICHK 206

  Fly   217 PATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCI 281
            |:.||.:   |.|  :.||||.|.:.||.|||.:|:||||:..:.|.:.|||||..:|||:||.|
Zfish   207 PSRKNVQ---DDL--YEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTLSI 266

  Fly   282 SILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLV 346
            |:|::||||.||||:.:|.||||:|::..|::||||||:.||..:|.|||:|.|:||||:|...|
Zfish   267 SVLIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPSTHHMPGWV 331

  Fly   347 RKLFLHFMPKLMMMRRTQYTLP---DYDDSTPSNGYTN------EIDVRDSISDFPSEFKDSQDG 402
            ||:|::.:|:.:.:.|.....|   :..::.|.....|      |..:|....:....::.|.:.
Zfish   332 RKVFINLLPRYLGVLRPTPEEPVEEEPKENVPMGCLGNSLRPGGEYFIRKINPELVMPWRGSHNE 396

  Fly   403 AYDNGMQNSVDSDN---VIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFF 464
            :... :|...:|||   ::|.||.    .|:.|:.::::.:|..|.|:.:.:||:::::||||.|
Zfish   397 STVK-LQRFSNSDNYCLILPPNLK----SAIAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLF 456

  Fly   465 LWLFTLSCVFGTLAIICQSPSLYDTRSP 492
            ||||.:....|||.:...:...|....|
Zfish   457 LWLFVVITTLGTLTMFLDASFNYTPDQP 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	186/468 (40%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	90/218 (41%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	186/470 (40%)
		Neur_chan_LBD	20..230	CDD:280998	89/215 (41%)
		Neur_chan_memb	237..472	CDD:280999	90/239 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910