Protein Alignment nAChRbeta2 and chrnb5a

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_021332008.1
• Gene: chrnb5a / 100003503
• ZFINID: ZDB-GENE-090312-169
• Length: 494
• Species: Danio rerio
• Alignment Length: 517
• Identity: 226/517 - (43%)
• Similarity: 317/517 - (61%)
• Gaps: 73/517 - (14%)

  Fly     7 LCVFLLVPLANSTAPISFEANPDTKRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            ||:..|. :|.|.|..:.|      ||.|.||  ..||:||||.||.::.:|:.:.:.|:|||.|
Zfish    13 LCLLWLC-VARSLAADAEE------RLVDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISV 70

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            |.:.|:||||:|:.|.|.||:|.|||.||.|:::|.:||.|||:||||||||.||.|||:....|
Zfish    71 NEREQIMTTNVWLTQEWNDYRLVWDPNEYEGIKKLRIPSRHIWLPDIVLYNNADGVYEVSFYCNA 135

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .:..||::||.|||||||:|.:.|..||:|:|.|.:||.||||:..::||.........:
Zfish   136 VVSNTGDIFWLPPAIYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLYLTSDFASRD----- 195

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTV 264
                ::..|.||||:.:|..:||:....|   :.|:|:...::||.||||:|||:|||.:|.|.:
Zfish   196 ----DYTPSGEWDIVSLPGRRNEDLSDPT---YLDVTYDFVIKRKPLFYTINLIIPCVLITSLAI 253

  Fly   265 LVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329
            ||||||||.|||:|||||:|::||||.||:::|:|||||||||:||||:|||:||:.|:.|:|||
Zfish   254 LVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCV 318

  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDD--------------STPSNGYT 380
            ||:|.||||||.|...|:::|||.:|..::|||     |...:              |:.:.|..
Zfish   319 LNVHHRSPSTHRMPEWVKRVFLHKLPFFLLMRR-----PGRSNVRERFRRKHQRKSFSSDTKGLR 378

  Fly   381 NEID---VRDS---------ISDFP--SEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALR 431
            .:.|   :.|.         :.|.|  |||:......:|                  |:|.:|:.
Zfish   379 LDGDSYFLSDDPGRVCGAWRVGDLPEGSEFRQRVKVRHD------------------PDVDEAIE 425

  Fly   432 AVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPI 493
            .|||||:|:|..|.|..|:||||:|:||:||.|||:|.|.||.|||.:..| |......:|:
Zfish   426 GVRFIAEHMKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFVQ-PLFQSYNTPV 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	221/499 (44%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/219 (44%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
chrnb5a	XP_021332008.1	LIC	20..474	CDD:455710	220/494 (45%)
		LGIC_ECD	31..234	CDD:475126	95/214 (44%)