Protein Alignment nAChRalpha2 and CHRNA6

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 217/533 - (40%)
• Similarity: 311/533 - (58%)
• Gaps: 85/533 - (15%)

  Fly    26 LCLLLVLL-------LLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLID 83
            |||.|.:.       :.|.|      .:||:..|.|:||:.||||.|.:|.|.|...:.::||.:
Human    14 LCLWLCVFTPFFKGCVGCAT------EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLAN 72

  Fly    84 LNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTK 148
            ::..:||:.||:||.|.|.|:|.:|||.||.|:..|.||::.||.|||||||||.|::.|...||
Human    73 VDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTK 137

  Fly   149 AILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE 213
            |:|.|.|.:.|||||||||||.:|:.:||||.|.|.:||||||||..:|||..|..|
Human   138 ALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK-------- 194

  Fly   214 IGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYL 278
              :|:.:::.:.||:|:.....:|:..|.||.|.|.||.::..:||..:|||:||||||:.||:|
Human   195 --VDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFL 257

  Fly   279 SVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITI 343
            :|||||||:|.|||:.||||:|||.|:|.|:|:|.||||||.:||:|:||||||:.|.||:|:|:
Human   258 TVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTV 322

  Fly   344 IILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMD 408
            .:||||||.|:||.|..|:::.|:|.||::||||.|.|..|...::.:..||
Human   323 FVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGL------------- 374

  Fly   409 EMQMNSGGSSPDSLRRMQGRVGAGG-------CNGMH----VTTATNRFSGLVGALGGGLSTLSG 462
                        :.|..:|::.:.|       |...|    :.|:..|.|
Human   375 ------------ARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLS--------------- 412

  Fly   463 YNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRL 527
                       ...|..|....::..|:|..|::|.||..:|:..:|....:.||.:||||:||:
Human   413 -----------HQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRV 466

  Fly   528 FLWLFMIASLVGT 540
            |||:|:|..:.||
Human   467 FLWVFIIVCVFGT 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	99/218 (45%)
		LIC	47..544	CDD:273305	211/505 (42%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	211/507 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980