DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and Chrna6

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_476532.2 Gene:Chrna6 / 81721 RGDID:69281 Length:493 Species:Rattus norvegicus


Alignment Length:503 Identity:209/503 - (41%)
Similarity:303/503 - (60%) Gaps:67/503 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 KRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDP 110
            ::|:..|.::|||.||||.|.:|.|.|...|.::||.:::..:||:.||:||.|.|:|::..|||
  Rat    35 EQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDP 99

  Fly   111 SEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRY 175
            :||.|:..|.||:::||.|||||||||.|::.|...|||:|.|.|.:.|||||||||||.:|:.:
  Rat   100 TEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITF 164

  Fly   176 FPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKY 240
            ||||.|.|.:||||||||..:|||..|..|          :|:.:::.:.||:|:.....:|:..
  Rat   165 FPFDHQNCSLKFGSWTYDKAEIDLLIIGSK----------VDMNDFWENSEWEIVDASGYKHDIK 219

  Fly   241 YPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTM 305
            |.||.|.|.||.::..:||..:|||:||||||:.||:|:|||||||:|.|||:.||||:|||.|:
  Rat   220 YNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 284

  Fly   306 FFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRL 370
            |.|:|:|.||||||.:||:|:||||||:.|.||:|:|:.:||||||.|:||.|..|:::.|::..
  Rat   285 FLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVF 349

  Fly   371 PKLLLMRVPKDLLRDLAANKINYGLKFSKT--------KFGQALMDEMQMNSGGSSPDSLRRMQG 427
            |.:|:||.|.|..::..      |:|..||        ||           :....|..|:.   
  Rat   350 PSILMMRRPLDKTKEAD------GVKDPKTHTKRPAKVKF-----------THRKEPKLLKE--- 394

  Fly   428 RVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEK 492
                  |...|.::..        |.|..||               ......||...::|.::|.
  Rat   395 ------CRHCHKSSEI--------APGKRLS---------------QQPAQWVAENSEHPPDVED 430

  Fly   493 AIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            .|.:|.||..:|:..:|....:.||.::|||:||:|||:|:|..:.||
  Rat   431 VIDSVQFITENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGT 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 98/216 (45%)
LIC 47..544 CDD:273305 209/502 (42%)
Chrna6NP_476532.2 LIC 34..483 CDD:273305 209/503 (42%)
LGIC_ECD 34..240 CDD:355788 98/214 (46%)
Cys-loop 158..172 CDD:349787 7/13 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I1995
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 477 1.000 Inparanoid score I1422
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm12327
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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