DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha2 and chrna2a

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001035417.1 Gene:chrna2a / 678575 ZFINID:ZDB-GENE-040108-2 Length:520 Species:Danio rerio


Alignment Length:565 Identity:249/565 - (44%)
Similarity:332/565 - (58%) Gaps:105/565 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLAHIWRHCKPLCLLLVLLLLCETVQ---------ANPDAKRLYDDLLSNYNRLIRPVSNNTDTV 70
            ||.::|          :|:|:.:.||         |:.:.| |:..|...||:..|||.|.:|.|
Zfish     9 LLNNLW----------MLILIADHVQPVLSDGWIHAHAEDK-LFHKLFIGYNKWSRPVRNISDVV 62

  Fly    71 LVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYN 135
            :||.||.::||||::.|:|::||||||:.||.|:|.:|:|||:..||.:.||||.||:|||||||
Zfish    63 IVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYN 127

  Fly   136 NADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLK 200
            |||||:.||.||||.|.:||||.|.||||:||||.|||.:||||||.|.|||||||||..:|||:
Zfish   128 NADGEFAVTHMTKAHLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE 192

  Fly   201 HISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYT 265
                      ::|..:||::|:.|.||.|:......:.|.|.||.|.||||.:...:||..||||
Zfish   193 ----------QIEGTVDLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYT 247

  Fly   266 VNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLF 330
            :||||||:.||.|:|||||||:|.||||.||||:|||.|:|.|||:||||||||.:||:|:||||
Zfish   248 INLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLF 312

  Fly   331 TMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGL 395
            ||:.|.||:|||:.:||:|:|.||||.|..|:.|.|:..:|:.|.||.|:...:.    |....|
Zfish   313 TMIFVTLSIVITVFVLNVHHRSPSTHSMPRWVHSVFLDHIPRWLFMRRPEPEKKP----KKTANL 373

  Fly   396 KFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGG--CNGMHVTTATNRFSGLVGALGGGLS 458
            ..||:.|                       |...|..|  |..|.              .|.|||
Zfish   374 STSKSWF-----------------------QQETGVDGLVCQDME--------------FGIGLS 401

  Fly   459 T-LSGYNGLPSVLS-GLDDS-----------LSDVAARKKYPFELE---------------KAIH 495
            | :|.    ||..| .|.||           |..|....::|.:|.               :|:.
Zfish   402 TSISS----PSATSLHLSDSEPLLQKYELQHLGHVVNLCQHPAKLGNLVSEPGLLFSPCVLRALE 462

  Fly   496 NVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            .|.:|..|::.:||..:..:||.:||||:||:|||:|:|..|:||
Zfish   463 GVRYIADHLRAEDEDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGT 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 116/218 (53%)
LIC 47..544 CDD:273305 240/524 (46%)
chrna2aNP_001035417.1 LIC 9..513 CDD:273305 249/565 (44%)
Neur_chan_LBD 37..243 CDD:280998 116/216 (54%)
Neur_chan_memb 250..511 CDD:280999 120/303 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2065
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I1461
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm6399
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.880

Return to query results.
Submit another query.