Protein Alignment nAChRalpha2 and Chrna9

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_075219.2
• Gene: Chrna9 / 65024
• RGDID: 621534
• Length: 479
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 178/538 - (33%)
• Similarity: 285/538 - (52%)
• Gaps: 63/538 - (11%)

  Fly    11 RPIALLAHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVL-VKL 74
            ||.:.|:..|.:.....:..|     ||.... .|::|:.||..:|:..:||| .:||.|| |.|
  Rat     3 RPHSCLSFCWMYFAASGIRAV-----ETANGK-YAQKLFSDLFEDYSSALRPV-EDTDAVLNVTL 60

  Fly    75 GLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139
            .:.|||:.|::.::||||..:|:...|.|....||..:|..:..:.:||:.:|.|||||||.||.
  Rat    61 QVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADD 125

  Fly   140 EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQ 204
            |......|..:|.|.|.:.|..|||.||||.:||.|||||.|.|.:.||||||:|:|:|:
  Rat   126 ESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDI----- 185

  Fly   205 KNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLI 269
                .|.::.| ||.::...|||::.|:||.::...|.||:|||||:.|.:.|:|::.||.|||:
  Rat   186 ----FNALDSG-DLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLL 245

  Fly   270 IPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLL 334
            ||||.||:|:.|.|||||.||||::|.::|||:.|:|.|:::||:|: |..:||:|||.:.||.|
  Rat   246 IPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMAL 309

  Fly   335 VGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSK 399
            :..|..:||:::|||:.......:..|.:...:|.:.::|.:                |.:
  Rat   310 ITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFV----------------YDV---- 354

  Fly   400 TKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYN 464
               |::.:....    ...|:.:.::..::...     ::.|:.|:.......:...|....||.
  Rat   355 ---GESCLSPRH----SQEPEQVTKVYSKLPES-----NLKTSRNKDLSRKKEVRKLLKNDLGYQ 407

  Fly   465 GLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFL 529
            |      |:..:.....||      .|....|:.:|...::.....|::..:|..||.|:||.|:
  Rat   408 G------GIPQNTDSYCAR------YEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFM 460

  Fly   530 WLFMIASLVGTFVILGEA 547
            |:|.....|.|.:|:..|
  Rat   461 WIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	92/219 (42%)
		LIC	47..544	CDD:273305	168/497 (34%)
Chrna9	NP_075219.2	LIC	8..474	CDD:273305	174/527 (33%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	92/216 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810