DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrna10

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_006229953.1	Gene:	Chrna10 / 64574	RGDID:	620142	Length:	492	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	166/506 - (32%)
Similarity:	250/506 - (49%)	Gaps:	92/506 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWD 109
            |.:|:.||.:||...:|||::...|:.|.|.:.|||:||::.::|:||..:|:..||.|....||
  Rat    75 AHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWD 139

  Fly   110 PSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVR 174
            |..||.:..:.:||..:|.|||||||.||.:...:..|..::.:.|.|.|..|||.:|||.:||.
  Rat   140 PKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVS 204

  Fly   175 YFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEK 239
            .||||.|.|.:.|||||:.|.|:|::...          ....|.::..:|||.:||:||.|...
  Rat   205 AFPFDAQRCGLTFGSWTHGGHQLDVRPRG----------TSASLADFVENVEWRVLGMPARRRVL 259

  Fly   240 YYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQT 304
            .|.||:|||||:.|.:.|||:...|..||::|||.||.|:.|.|:||||||||::|.:::||:.|
  Rat   260 TYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALT 324

  Fly   305 MFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKR 369
            :|.|:::|.:|... ::||:|||.:.||.:|..|..:||:|:|:||..|:.|.:..|.|...:..
  Rat   325 VFQLILAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGH 388

  Fly   370 LPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSP-DSLRRMQGRVG--A 431
            |.|.|.:|                               |.....|.|.| :|...:|....  |
  Rat   389 LAKGLCVR-------------------------------ERGEPCGQSKPLESAPSLQPPPASPA 422

  Fly   432 GGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHN 496
            |.|:.                              |..|.                 ..|..:|:
  Rat   423 GPCHE------------------------------PRCLC-----------------HQEALLHH 440

  Fly   497 VMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEA 547
            :..|....:.........:||..:|.||||.||.:|...:||.:.::|.:|
  Rat   441 IASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	88/217 (41%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	163/499 (33%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:273305	161/489 (33%)
		Neur_chan_LBD	77..280	CDD:280998	86/212 (41%)
		Neur_chan_memb	288..482	CDD:280999	72/272 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810