Protein Alignment nAChRalpha2 and htr3a

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: XP_009293684.1
• Gene: htr3a / 571641
• ZFINID: ZDB-GENE-071012-5
• Length: 482
• Species: Danio rerio
• Alignment Length: 527
• Identity: 126/527 - (23%)
• Similarity: 249/527 - (47%)
• Gaps: 93/527 - (17%)

  Fly    41 ANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHK 105
            ||....||.:.|.:.|.:.:|||.:...:..|.:.|.:..:::::.|:|:|||.||...:|.|..
Zfish    34 ANATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAIDLMVYAILNVDEKNQVLTTYVWYRQQWTDEF 98

  Fly   106 FKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAI----LHYTGKVVWTPPAIFK 166
            ..|||.|:..|.::.:|:.:||:|||::     .|:|....:..|    :.:.|.|....|....
Zfish    99 LMWDPEEFDEVKKISIPTANIWIPDILI-----NEFVDVGKSPDIPYVYVGHDGLVSNYKPIQVV 158

  Fly   167 SSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHI----SQKNDKDNKVEIGIDLREYYPSVEW 227
            ::|.:::..||:|.|.|.:.|.||.:....|::..:    :.|.||...:..|          ||
Zfish   159 TACSLNIYNFPYDVQKCSLTFQSWLHTTKDINITLMRSPEAVKTDKSVFMNQG----------EW 213

  Fly   228 DILGVPAE------RHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLP 286
            ::|.|.:.      .::.|       |.::.|::.:||:.|||||||::|.:.:..:.::.||||
Zfish   214 ELLHVLSTYNAFSIDNDDY-------YAEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLP 271

  Fly   287 ADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYR 351
            .||||:::..|::||..::|.:::|:.:|:|::..||:|.|.:..|.|:.:|:..:::|:.:.::
Zfish   272 PDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHK 336

  Fly   352 KPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGG 416
            :....::..|::...:::...||.:|..|.             ..|........|..|..||:
Zfish   337 QDLQSRVPQWVKHLVLEKATVLLCIRNKKI-------------CSFRSQGSDLPLYKENNMNT-- 386

  Fly   417 SSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVA 481
                          |..||  |.:...:|.||....||     ||.:...|.|:.|:
Zfish   387 --------------AIHCN--HHSCEGSRDSGRTLGLG-----LSAHESGPPVMDGI-------- 422

  Fly   482 ARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGE 546
                        :..:..|:..::::||.....::|..|..|:|.|...:::: :::...:.||.
Zfish   423 ------------LREITTIRQFLEKKDESREIAKEWLQVGYVLDILLFRVYLL-TVLAYGITLGS 474

  Fly   547 APSLYDD 553
            ..|::.:
Zfish   475 LWSIWQN 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	58/232 (25%)
		LIC	47..544	CDD:273305	121/510 (24%)
htr3a	XP_009293684.1	LIC	21..479	CDD:273305	126/523 (24%)
		Neur_chan_LBD	40..246	CDD:280998	58/227 (26%)
		Neur_chan_memb	253..479	CDD:280999	60/282 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810