Protein Alignment nAChRalpha2 and CHRNA10

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_065135.2
• Gene: CHRNA10 / 57053
• HGNCID: 13800
• Length: 450
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 181/542 - (33%)
• Similarity: 269/542 - (49%)
• Gaps: 114/542 - (21%)

  Fly    22 HCKPLCLLLVLLLLCETVQANPD-AKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLN 85
            |...|.|||:.||..|.:.|... |.:|:.||.:||...:|||::...|:.|.|.:.|||:||::
Human     6 HHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMD 70

  Fly    86 LKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAI 150
            .::|:||..:|:..||.|...:|||:.|||:..:.:||..:|.|||||||.||.:...:..|..:
Human    71 ERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVV 135

  Fly   151 LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIG 215
            |.:.|.|.|..|||.:|||.:||..||||.|.|.:.|||||:.|.|:|::...          ..
Human   136 LRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRG----------AA 190

  Fly   216 IDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSV 280
            ..|.::..:|||.:||:||.|....|.||:|||||:.|.:.|||:...|..||::|||.||.|:.
Human   191 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAP 255

  Fly   281 LVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIII 345
            |.|:||||||||::|.:::||:.|:|.||::|.:|... ::||:|||.:.||.:|..|..:||:|
Human   256 LAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILI 319

  Fly   346 LNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEM 410
            :|:||..||...:..|.|:..:..|.:.|.:|...:                   ..||:...|:
Human   320 MNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE-------------------PCGQSRPPEL 365

  Fly   411 ----QMNSGGSSPDSLRRMQGRVGAGGCNG-----------MHVTTATNRFSGLVGALGGGLSTL 460
                |...||:.|.          ||.|:.           .||.|..|.|.
Human   366 SPSPQSPEGGAGPP----------AGPCHEPRCLCRQEALLHHVATIANTFR------------- 407

  Fly   461 SGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMD 525
                             |..||::.:                            :||..:|.|||
Human   408 -----------------SHRAAQRCH----------------------------EDWKRLARVMD 427

  Fly   526 RLFLWLFMIASLVGTFVILGEA 547
            |.||.:|...:||.:.::|.:|
Human   428 RFFLAIFFSMALVMSLLVLVQA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	90/219 (41%)
		LIC	47..544	CDD:273305	169/511 (33%)
CHRNA10	NP_065135.2	LIC	31..442	CDD:273305	169/508 (33%)
		Neur_chan_LBD	32..235	CDD:280998	88/212 (42%)
		Neur_chan_memb	243..434	CDD:280999	75/278 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..380		7/53 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810