Protein Alignment nAChRalpha2 and Htr3b

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_064670.1
• Gene: Htr3b / 57014
• MGIID: 1861899
• Length: 437
• Species: Mus musculus
• Alignment Length: 398
• Identity: 105/398 - (26%)
• Similarity: 182/398 - (45%)
• Gaps: 43/398 - (10%)

  Fly    27 CLLLVLLLLCETVQANP---DAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKD 88
            |||:.::.:..|....|   ...||...||..|::.:|||.|..:...|.|.|.:..::|:::::
Mouse     7 CLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQN 71

  Fly    89 QILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGE------YVVTTMT 147
            |.|.|:||....|.|....|:.|.:..:.|:.:|...:|.|||::....|.|      ||....:
Mouse    72 QKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSS 136

  Fly   148 KAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKV 212
            ..|.::       .|....|:|.:....||||.|.|.:.|.|..:..:.|||..:..:.|.:|
Mouse   137 GTIRNH-------KPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIEN-- 192

  Fly   213 EIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISY 277
                |.|.:....||.:|.|.:..|.:  ...|..:..|.||:.:||..|.|.|:|:||.:.:..
Mouse   193 ----DKRAFMNDSEWQLLSVSSTYHIR--QSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLML 251

  Fly   278 LSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVIT 342
            :.:..||||.:...:|....::|:..|:|.:.:|:.:|.::...||:|.:....|.|:.||:..:
Mouse   252 VDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKS 316

  Fly   343 IIILNIHYRKPSTHKMRPWI-----------RSFF------IKRLPKLLLMRVPKDLLRD--LAA 388
            |:::...|.:..:.:.||.:           |.:.      :...|.....|||.|.|:|  ...
Mouse   317 ILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQF 381

  Fly   389 NKINYGLK 396
            ..||..|:
Mouse   382 RSINNSLR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	62/224 (28%)
		LIC	47..544	CDD:273305	100/375 (27%)
Htr3b	NP_064670.1	LIC	30..431	CDD:273305	100/375 (27%)
		Neur_chan_LBD	30..233	CDD:280998	60/217 (28%)
		Neur_chan_memb	242..>313	CDD:280999	19/70 (27%)
		HA-stretch	377..409		3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810