DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrnb5b

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_017214550.1	Gene:	chrnb5b / 569662	ZFINID:	ZDB-GENE-120809-5	Length:	475	Species:	Danio rerio

Alignment Length:	548	Identity:	208/548 - (37%)
Similarity:	307/548 - (56%)	Gaps:	93/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IAL-LAHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLS--NYNRLIRPVSNNTDTVLVKL 74
            :|| :|.:|               |..|:     :||.:.|||  .||:||||..|.:..|.:.:
Zfish    12 VALTMATVW---------------CAEVE-----ERLVNYLLSPDRYNKLIRPAVNKSQQVTIAI 56

  Fly    75 GLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139
            .:.|:|||.:|.::||:|||.||...|.|::..|||.||.|:.::.:||:|||||||||||||||
Zfish    57 QVSLAQLISVNEREQIMTTNCWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADG 121

  Fly   140 EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQ 204
            .|.|:..:.|::...|:|.|.||||:||:|:|:||.||||||.|.:||.|||||..:|||..:|.
Zfish   122 TYEVSFYSNAVVSNNGEVAWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLSD 186

  Fly   205 KNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYT 265
            ...:|          ::.||.||||:.:|..::|       :|    |.||.::..:|||.||||
Zfish   187 FASRD----------DFKPSGEWDIVSLPGRKNE-------DPNDVTYLDITYDFIIRRKPLFYT 234

  Fly   266 VNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLF 330
            :|||||||.|:.|::||||||:|.||||.||||:||:.|:|.||||:|:|.||||:||:||||:|
Zfish   235 INLIIPCVLITSLAILVFYLPSDCGEKITLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMF 299

  Fly   331 TMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGL 395
            ||:||..|:|.::.:||:|:|.||||.|..|::.:|:.|||..|.||.|.:      :||.:
Zfish   300 TMVLVTFSIVTSVCVLNVHHRSPSTHSMPKWVKYYFLVRLPAFLFMRRPGE------SNKRD--- 355

  Fly   396 KFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFS-GLVGALGGGLST 459
            :| :.|..|....::.:.|.....||                  |...|..| ..:|...|.|..
Zfish   356 RF-RRKHQQHSSSDVPVKSEADEADS------------------TFFVNEDSANHIGWRAGELQE 401

  Fly   460 LSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVM 524
            .|......:|               |...::|:|:..|.:|...|:.:|    :|:...|:.:..
Zfish   402 NSELRKRMAV---------------KCSADMEEAVKGVRYIADKMKSED----DDEGVSFIHVFG 447

  Fly   525 DRLFLWLFMIASLVGTFVILGEAPSLYD 552
            ..::.....:. :|.|::.|.|..:..:
Zfish   448 KNMYTKKLCLL-VVSTYLKLAETTNFLE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	100/224 (45%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	200/503 (40%)
chrnb5b	XP_017214550.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920