DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrna2b

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_697298.4	Gene:	chrna2b / 568849	ZFINID:	ZDB-GENE-041001-99	Length:	550	Species:	Danio rerio

Alignment Length:	565	Identity:	247/565 - (43%)
Similarity:	337/565 - (59%)	Gaps:	88/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LCLLLVLLLLCETV----QANPDAK-RLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLN 85
            |.:.|:..::||::    :.:..|: .|:..|...||:..|||.|.:|.|:||.||.::||||::
Zfish    11 LRITLLCTIICESISCCEKTHSHAEDELFKKLFDGYNKWSRPVPNTSDVVIVKFGLSIAQLIDVD 75

  Fly    86 LKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAI 150
            .|:|::||||||:.||.|:|.:|.||:|..||.:.||||.||:||||||||||||:.||.||||.
Zfish    76 EKNQMMTTNVWLKQEWNDYKLRWKPSDYDNVTSIRVPSELIWVPDIVLYNNADGEFAVTHMTKAH 140

  Fly   151 LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIG 215
            |.:||||.|.||||:||||.|||.:||||||.|.|||||||||..:|||:          ::|..
Zfish   141 LFHTGKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE----------RIENT 195

  Fly   216 IDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSV 280
            :||::|:.|.||.|:......:.|.|.||.|.||||.:...:||..||||:||||||:.||.|:|
Zfish   196 VDLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTV 260

  Fly   281 LVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIII 345
            ||||||:|.||||.||||:|||.|:|.|||:||||||||.:||:|:||||||:.|.||:|||:.:
Zfish   261 LVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 325

  Fly   346 LNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVP--------KDLLRD-----LAANKINYGLKF 397
            ||:|:|.||||||..|:.|.|:..:|:.|.||.|        |.||..     :.|...|..|..
Zfish   326 LNVHHRSPSTHKMPCWVHSVFLDLIPRWLFMRRPAPDSRRRQKLLLLQRQVPGMTARPANASLST 390

  Fly   398 SKTKF-GQ-----------------------ALMDEMQMNSG---GSSPDSLRRMQGRVGAGGCN 435
            |.:.| ||                       |:...:|.:|.   |.:|..|::.      |...
Zfish   391 STSWFRGQNSGEDESCRHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQKF------GPAP 449

  Fly   436 GMHVTTATNRFSGLVGALGGGLSTL-----SGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIH 495
            .:.|.||:.:.||... :...|..:     .|:...||||                     :|:.
Zfish   450 RLEVGTASRQLSGRAN-VTKRLDNMIPHDNPGFPLSPSVL---------------------QALE 492

  Fly   496 NVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            .|.:|..|::.:|...:..:||.:||||:||:|||:|:|..|:||
Zfish   493 GVHYIADHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGT 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	116/219 (53%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	242/539 (45%)
chrna2b	XP_697298.4	LIC	6..543	CDD:273305	247/565 (44%)
		Neur_chan_LBD	35..241	CDD:280998	115/215 (53%)
		Neur_chan_memb	248..541	CDD:280999	122/318 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1461
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm6399
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.980