Protein Alignment nAChRalpha2 and chrna11

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 606
• Identity: 201/606 - (33%)
• Similarity: 316/606 - (52%)
• Gaps: 96/606 - (15%)

  Fly    19 IWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLID 83
            :| |.....|..:..|:..:|| .|..:.|..:||.:|||:.|||:|::..:.|.|.:.|.|::|
Zfish     1 MW-HSLAFTLCGISALIQVSVQ-GPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMD 63

  Fly    84 LNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTK 148
            ::.|:|:||||:||...|.||..:|:.|||.||..|...::.:|.|||:|||:||.::..|..:.
Zfish    64 VDEKNQVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSN 128

  Fly   149 AILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE 213
            .:::.:|...:.||.||.|:|.:|||:||||.|.|.:||||||:||..:||    |.|:
Zfish   129 VVVNSSGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDL----QMNE------ 183

  Fly   214 IGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYL 278
              .|:..|.|:.|||::|||..|:|.:|.||.|||||:.|.:|:||:||:|.:||:||||.:|.:
Zfish   184 --ADISGYMPNGEWDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSM 246

  Fly   279 SVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITI 343
            ::|:|.|||||||||:|.|::|||.|:|.||::||:|:||.::||:|:|....|::||:||:.|:
Zfish   247 TLLIFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATV 311

  Fly   344 IILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVP---KDLLRDLAANKINYGLKFSKTKFGQA 405
            ::|..|:..|:...|..|::...::.:...|.|:.|   :|..|...|..:.        :....
Zfish   312 VVLQYHHHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLR--------RCSSG 368

  Fly   406 LMDEMQMNSGGSS-----------------PDSLRRMQGRVGAGGCNGMH--VTTATNR------ 445
            .......|:.||:                 |.||  :|....||..:.:|  ..:|.|.
Zfish   369 SQSGSLPNAPGSASADLHHHHISSTLHPLHPQSL--LQAAAAAGHTHHLHNQTNSANNNGNLLYI 431

  Fly   446 -FSGLVGALGGGL-------STLSG------------------------------------YNGL 466
             ||.|..|....|       :::||                                    ..|.
Zfish   432 GFSSLDEASPPALLADSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGC 496

  Fly   467 PSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWL 531
            ||.:||.....|..........:|:..:..|.::....:.|||..:..:.|.|.|.|:|||.|..
Zfish   497 PSTVSGGGGGCSCSGTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCLVA 561

  Fly   532 FMIASLVGTFVILGEAPSLYD 552
            |.:.:::.|..||..||:..:
Zfish   562 FSVFNIICTISILMSAPNFVE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	95/218 (44%)
		LIC	47..544	CDD:455710	190/568 (33%)
		Cys-loop	169..183	CDD:349832	9/13 (69%)
chrna11	NP_001038562.1	LIC	2..577	CDD:455710	199/598 (33%)