DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrnb2

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_005169811.1	Gene:	chrnb2 / 561906	ZFINID:	ZDB-GENE-070821-3	Length:	543	Species:	Danio rerio

Alignment Length:	543	Identity:	221/543 - (40%)
Similarity:	329/543 - (60%)	Gaps:	53/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LCLLLVLLLLCETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKD 88
            |..|..:|.:.::.......:||.:.||  ::||:||||.:|.::.|.|:|.:.|:|||.::.::
Zfish     4 LWTLFCILAIVKSGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHERE 68

  Fly    89 QILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHY 153
            ||:||||||..||||::..|.|.|:.|:.::.:||:||||||:||||||||.|.|:..:.|::.|
Zfish    69 QIMTTNVWLTQEWQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSY 133

  Fly   154 TGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDL 218
            .|.|.|.||||:||:|:|:|::||||||.|.:.|.|||||..::||...:.....|
Zfish   134 DGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLRADVASMD--------- 189

  Fly   219 REYYPSVEWDILGVPAERHEKYYPCCAEP-YPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLV 282
             ::.||.||||:.:|..|:|.  |  ::| |.||.::..:|||.||||:|||||||.|:.|::||
Zfish   190 -DFTPSGEWDIIALPGRRNEN--P--SDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILV 249

  Fly   283 FYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILN 347
            ||||:|.|||:.||||:||:.|:|.||||:|:|.|||.:||:||||:|||:||..|:|.::.:||
Zfish   250 FYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLN 314

  Fly   348 IHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKD------LLRDLAANKINYGLKFSKTKFGQAL 406
            :|:|.|:||.|.||::..|:.:||.||.||.|::      |.:...||:...|   .:......|
Zfish   315 VHHRSPTTHTMPPWVKLVFLNKLPALLFMRQPRNSSERQRLRQRRRANEQQEG---GRGGLAAGL 376

  Fly   407 MDEMQM--NSGGSSPD-----------SLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLS 458
            |..:.:  :|.||..:           |:::....:|.||..|       ....||.|...||..
Zfish   377 MAGLGLSGSSSGSKENNEACTCYVNRASVKQFGAELGGGGGGG-------GSTDGLNGIREGGRE 434

  Fly   459 TLSG------YNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDW 517
            |..|      .:.||.........|:.....:..| ..|:|:..|.||.:||:.:|:..:..:||
Zfish   435 TREGGANPLQGSALPRGKQQPPTVLTQALLAQACP-GFEEAVDGVRFIANHMKSEDDDRSVSEDW 498

  Fly   518 GFVAMVMDRLFLWLFMIASLVGT 540
            .:||||:||||||:|:...:.||
Zfish   499 KYVAMVIDRLFLWIFVFVCVFGT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	99/221 (45%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	218/522 (42%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:273305	221/543 (41%)
		Neur_chan_LBD	23..228	CDD:280998	98/218 (45%)
		Neur_chan_memb	235..525	CDD:280999	114/298 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820