Protein Alignment nAChRalpha2 and CHRNA9

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 186/542 - (34%)
• Similarity: 283/542 - (52%)
• Gaps: 80/542 - (14%)

  Fly    20 WRH-CKPLCLLLVL---LLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVL-VKLGLRLS 79
            |.| |...|.:...   |...||.... .|::|::||..:|:..:||| .:||.|| |.|.:.||
Human     3 WSHSCISFCWIYFAASRLRAAETADGK-YAQKLFNDLFEDYSNALRPV-EDTDKVLNVTLQITLS 65

  Fly    80 QLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVT 144
            |:.|::.::||||..:|:...|.|....||..:|.|:..:.:||:.:|.|||||||.||.|....
Human    66 QIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEP 130

  Fly   145 TMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKD 209
            ..|..:|.|.|.:.|..|||.||||.:||.|||||.|.|.:.||||||:|:|:|:         .
Human   131 VNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI---------F 186

  Fly   210 NKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVG 274
            |.::.| ||.::...|||::.|:||.::...|.||:|||||:.|.:.|:|::.||.|||:||||.
Human   187 NALDSG-DLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVL 250

  Fly   275 ISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSV 339
            ||:|:.|.|||||.||||::|.::|||:.|:|.|:::||:|: |..:||:|||.:.||.|:..|.
Human   251 ISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITAST 314

  Fly   340 VITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQ 404
            .:||:::|||:.......:..|.|...:|.:.::|.:                |.:       |:
Human   315 ALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFV----------------YDV-------GE 356

  Fly   405 ALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRF--SGLVGALGGGLSTLSGYNGLP 467
            :.:          ||...|...           |:|...::.  |.|..|....||.....|
Human   357 SCL----------SPHHSRERD-----------HLTKVYSKLPESNLKAARNKDLSRKKDMN--- 397

  Fly   468 SVLSGLDDSLSDVAARKKYPFELEK-------AIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMD 525
                  ....:|:..:.|.|.|.|.       ...|:.:|...::.....|::..:|..||.|:|
Human   398 ------KRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVID 456

  Fly   526 RLFLWLFMIASLVGTFVILGEA 547
            |.|:|:|.|...|.|.:|:..|
Human   457 RFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	93/219 (42%)
		LIC	47..544	CDD:273305	176/506 (35%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:273305	181/529 (34%)
		Neur_chan_LBD	31..236	CDD:280998	92/215 (43%)
		Neur_chan_memb	244..474	CDD:280999	80/283 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810