DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and chrna6

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001036149.1 Gene:chrna6 / 555747 ZFINID:ZDB-GENE-090312-91 Length:512 Species:Danio rerio


Alignment Length:517 Identity:220/517 - (42%)
Similarity:322/517 - (62%) Gaps:35/517 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTN 94
            |::.|:.:...::....||:..|...||:.||||.|.:|.|.|:..:.:|||:.::..:||:.||
Zfish    12 LLITLITQDCFSSKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETN 76

  Fly    95 VWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVW 159
            :||.|.|.|:|.||.|:|:.|:..:.|||..||.|||||||||.|:::|...|||:|.:.|.:.|
Zfish    77 LWLRHIWNDYKLKWSPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKFDGTITW 141

  Fly   160 TPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPS 224
            .|||||||||.:|:.|||||.|.|.|||||||||..:|||..|..|          ::|::::.|
Zfish   142 VPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVLIGSK----------VNLKDFWES 196

  Fly   225 VEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADS 289
            .||:|:..|..:|:..|.||.|.||||.::..:||..||||:||||||:.||:|:|||||||:|.
Zfish   197 GEWEIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC 261

  Fly   290 GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPS 354
            |||:.||||:|||.|:|.|:|:|.||||||.:||:|:||||||:.|.||:|||:.:||:|||.|.
Zfish   262 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPM 326

  Fly   355 THKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGG--S 417
            ||.|..|:.:.|::.||:::|||.|.||........:..| ..|.|..|:....:.:.|||.  .
Zfish   327 THTMPSWVHTVFLRALPRIMLMRRPLDLSESSGKGGLETG-GSSGTGAGRGGEGKKRKNSGSQQG 390

  Fly   418 SPDSLRRMQGRVG----AGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLS 478
            :.:||...:|:..    .|||....:..||   .|..|.:...||               ..:::
Zfish   391 AMNSLEFGEGKAALEGKKGGCPCHPLKEAT---EGDCGKVSRQLS---------------PQAIN 437

  Fly   479 DVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGT 540
            .|.|......|:::||.:|.:|..:|:.:::....:.||.:||||:||:|||:|::..::||
Zfish   438 TVVAFSVVSPEIKQAIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGT 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 101/218 (46%)
LIC 47..544 CDD:273305 218/500 (44%)
chrna6NP_001036149.1 LIC 38..504 CDD:273305 215/491 (44%)
Neur_chan_LBD 38..233 CDD:280998 98/204 (48%)
Neur_chan_memb 240..503 CDD:280999 112/279 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2065
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I1461
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm6399
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.980

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