DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrna5

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001017885.1	Gene:	chrna5 / 550584	ZFINID:	ZDB-GENE-050417-440	Length:	466	Species:	Danio rerio

Alignment Length:	543	Identity:	207/543 - (38%)
Similarity:	304/543 - (55%)	Gaps:	113/543 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LCLLLVLL-LLCETV--------QANPDAK---RLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRL 78
            |.|:..|| |:|..|        ..:..||   :|:..|.|||.:.:||:.:...|:.||.||.:
Zfish     5 LSLVRALLPLVCSAVLCSAIGPPMLSSYAKTEDKLFKHLFSNYQKWVRPIEDLNTTIQVKFGLAI 69

  Fly    79 SQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVV 143
            |||:|::.|:|::|||||::.||.|.|.:|||..|.|:|.:.|||:.||:||||||:||||.: .
Zfish    70 SQLVDVDEKNQLMTTNVWMKQEWTDLKLRWDPDHYLGITSIRVPSDSIWIPDIVLYDNADGNF-E 133

  Fly   144 TTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDK 208
            .|:|||::.:.|.:.|||||.:||:|.|||.:||||.|.|.||||||||||.|:|:.
Zfish   134 ATVTKAVVRFDGTISWTPPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIL-------- 190

  Fly   209 DNKVEIGIDLREYYPSVEWDILGVPAERHEK----YYPCCAEPYPDIFFNITLRRKTLFYTVNLI 269
              ..::.:|.|:|:.:.||:|:.....|..:    ::      ||.|.::..:||..||||:.||
Zfish   191 --LEDVHVDKRDYFDNGEWEIVKATGNRGLRRDGTFF------YPSITYSFIIRRLPLFYTLFLI 247

  Fly   270 IPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLL 334
            |||:|:|:|:|||||||::.||||:||.|:|:|.|:|.|:|.|||||:|..:||:|:||:|||:.
Zfish   248 IPCIGLSFLTVLVFYLPSNGGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIF 312

  Fly   335 VGLSVVITIIILNIHYRKPST-HKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFS 398
            |.||:|||:..:|||:|..|| |.|.||:|..|:..||:||.||
Zfish   313 VTLSIVITVFAINIHHRSSSTHHSMAPWVRRIFLHHLPRLLCMR--------------------- 356

  Fly   399 KTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGY 463
                                                  .||    :|::...|...|||
Zfish   357 --------------------------------------SHV----DRYATSAGTRTGGL------ 373

  Fly   464 NGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLF 528
                    |...|||....:......|:.|:.::.:|..|:.:::|.....|||.|||.|:||:|
Zfish   374 --------GYGKSLSQDTNQLDAEHNLQAALESIRYITRHVVKENEVREVVQDWKFVAQVLDRVF 430

  Fly   529 LWLFMIASLVGTFVILGEAPSLY 551
            ||.|::.||:|:.::.  .|.:|
Zfish   431 LWAFLLVSLLGSALLF--IPVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	96/225 (43%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	196/501 (39%)
chrna5	NP_001017885.1	LIC	12..448	CDD:273305	202/531 (38%)
		Neur_chan_LBD	36..239	CDD:280998	94/219 (43%)
		Neur_chan_memb	246..446	CDD:280999	98/276 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830