DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrna10

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001074893.1	Gene:	Chrna10 / 504186	MGIID:	3609260	Length:	447	Species:	Mus musculus

Alignment Length:	523	Identity:	174/523 - (33%)
Similarity:	259/523 - (49%)	Gaps:	93/523 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLVLLLLCETVQANPD-AKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILT 92
            ||:|.|..|.:.|... |.:|:.||.:||...:|||::...|:.|.|.:.|||:||::.::|:||
Mouse    13 LLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLT 77

  Fly    93 TNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKV 157
            ..:|:..||.|....|||..||.:..:.:||..:|.|||||||.||.:...:..|..::.:.|.|
Mouse    78 LYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGAV 142

  Fly   158 VWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYY 222
            .|..|||.:|||.:||..||||.|.|.:.|||||:.|.|:|::...          ....|.::.
Mouse   143 RWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRG----------TSASLADFV 197

  Fly   223 PSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPA 287
            .:|||.:||:||.|....|.||:|||||:.|.:.|||:...|..||::|||.||.|:.|.|:|||
Mouse   198 ENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPA 262

  Fly   288 DSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRK 352
            |||||::|.:::||:.|:|.|:::|.:|... ::||:|||.:.||.:|..|..:||:|:|:||..
Mouse   263 DSGEKVSLGVTVLLALTVFQLILAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCG 326

  Fly   353 PSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGS 417
            |:.|.:..|.|...:..|.|.|.:|                               |.....|.|
Mouse   327 PNAHPVPAWARVLLLGHLAKGLCVR-------------------------------ERGEPCGQS 360

  Fly   418 SP-DSLRRMQGRVG--AGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSD 479
            .| :|...:|...|  ||.|:.                              |..|.
Mouse   361 KPLESAPSLQPPAGPPAGPCHE------------------------------PRCLC-------- 387

  Fly   480 VAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVIL 544
                     ..|..:|:|..|....:.........:||..:|.||||.||.:|...:||.:.::|
Mouse   388 ---------HQEALLHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLLVL 443

  Fly   545 GEA 547
            .:|
Mouse   444 VQA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	88/219 (40%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	165/499 (33%)
Chrna10	NP_001074893.1	LGIC_ECD	30..236	CDD:355788	88/215 (41%)
		LGIC_TM_cation	239..>324	CDD:349853	40/85 (47%)
		TM1 helix	239..261	CDD:349853	11/21 (52%)
		Neur_chan_memb	243..437	CDD:367256	74/272 (27%)
		TM2 helix	269..290	CDD:349853	7/20 (35%)
		TM3 helix	300..322	CDD:349853	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810