DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and chrne

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001314812.1	Gene:	chrne / 445315	ZFINID:	ZDB-GENE-040808-32	Length:	517	Species:	Danio rerio

Alignment Length:	543	Identity:	178/543 - (32%)
Similarity:	290/543 - (53%)	Gaps:	50/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQIL 91
            |::.:.||.........:..:|..|...||::.|||..:..:.|.|::.|.|:.||.||.|::.|
Zfish    11 CVVAIALLATVLQVTGNEESQLIADKFKNYSKNIRPARHADEKVKVQVKLTLTNLISLNEKEETL 75

  Fly    92 TTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGK 156
            |||||:|.:|.|::..|:.|||..:.::.||...:|||||||.||.||::.|......::...|.
Zfish    76 TTNVWIEIQWHDYRLAWNTSEYHDIEQIRVPYYTVWLPDIVLENNIDGKFDVAYYANVLISSDGS 140

  Fly   157 VVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE-IGIDLRE 220
            :.|.||||::|:|.|::.|||||.|.|.:.|.|.||..::||:.....:|.|  .:| :.||...
Zfish   141 MYWLPPAIYRSTCAIEITYFPFDWQNCTLVFRSQTYSANEIDIVLAEDENGK--PIEWVDIDPEA 203

  Fly   221 YYPSVEWDILGVPAER--HEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVF 283
            :..:.||.|...||.:  :::|.|...| |.::::||.::||.|||.:|:|:||..||.|.||.:
Zfish   204 FTENGEWAIKHRPARKLTNQRYSPDDLE-YQEVYYNIIIQRKPLFYVINIILPCSLISSLVVLAY 267

  Fly   284 YLPADS-GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILN 347
            :|||.: |:|:.:.||:||:||:|.:|||:.||.|||::||:||||:|.|.:..|.|...||:||
Zfish   268 FLPAKAGGQKLTVSISVLLAQTVFLILISQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLN 332

  Fly   348 IHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQM 412
            ...|.||||.|...|:..|::.:|:.|.|           |..::.|     .:.|...|.|.:.
Zfish   333 YSLRSPSTHNMSQSIKHIFLEVVPRYLGM-----------APFVDEG-----DQGGVYEMRERRR 381

  Fly   413 NSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSL 477
            :|.|    .::|.:..|.....:.|.......| .||:..:...:...|..|        |..||
Zfish   382 SSFG----LMQRAEEYVLKQPRSEMMFDKQRER-HGLMRTIVDEIDVSSTAN--------LYKSL 433

  Fly   478 SDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLW----LFMIAS-- 536
            :..|.      |:::.:....||....::|::..:|.:.|..:..::|::..|    ||.|.:
Zfish   434 AKTAP------EIKECVDACNFIAESTKQQNDTGSEMESWVLIGKMIDKVCFWAAISLFSIGTIA 492

  Fly   537 --LVGTFVILGEAPSLYDDTKAI 557
              |:|.:....|.|..:::.|.:
Zfish   493 IFLMGHYNQAPEYPFAWENKKYV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	83/221 (38%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	172/508 (34%)
chrne	NP_001314812.1	LIC	10..495	CDD:273305	173/521 (33%)
		Neur_chan_LBD	29..245	CDD:280998	82/218 (38%)
		Neur_chan_memb	252..494	CDD:280999	83/276 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810