Protein Alignment nAChRalpha2 and Grd

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 87/456 - (19%)
• Similarity: 154/456 - (33%)
• Gaps: 125/456 - (27%)

  Fly    40 QANPDA--KRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQ 102
            |:|..|  ..|.|:||..|:..|||........ :::.:.:..:..::..|...:.:.:....|.
  Fly   102 QSNNHANISELLDNLLRGYDNSIRPDFGGPPAT-IEVDIMVRSMGPISEVDMTYSMDCYFRQSWV 165

  Fly   103 DHKFKWDPSEYGGVTELYVPS----EHIWLPDIVLYNNADGE-YVVTTMTKAI-LHYTGKVVWTP 161
            |.:..::     |..:....|    ..||.||...||..... :.:||..|.: ::..|:|:::.
  Fly   166 DKRLAFE-----GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSS 225

  Fly   162 PAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVE 226
            ....|:.|.:::..||.|.|.|.:||||:.|....:    |.:.|.:...|.|..|::    ..:
  Fly   226 RLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDV----IYRWNKERPPVAIAEDMK----LSQ 282

  Fly   227 WDILGVPAERHEKYYPCCAEPYPD--IFFNITLRRKTLFYTVNLIIPC----------------- 272
            :|::..||..........|.|.|.  .|.|....|.|.........|.
  Fly   283 FDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGA 347

  Fly   273 --------------VGIS------------YLSVLV-FYLPADSGEKI-----ALCISILLSQTM 305
                          .|:|            |..::| |:|....|..:     ..|:.::||...
  Fly   348 FGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVS 412

  Fly   306 FFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRL 370
            |:|.........||                |::.|:|:..|.:..|........|....||:
  Fly   413 FWLNREATADRVSL----------------GITTVLTMTFLGLEARTDLPKVSYPTALDFFV--- 458

  Fly   371 PKLLLMRVPKDLLRDLAANKINYGLKFSK----------TKFGQA----LMDEMQMNSGGSSPDS 421
                               .:::|..|:.          ||:|..    :::|:...||.|..:.
  Fly   459 -------------------FLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEP 504

  Fly   422 L 422
            |
  Fly   505 L 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	52/228 (23%)
		LIC	47..544	CDD:273305	84/447 (19%)
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	51/229 (22%)
		LIC	111..670	CDD:273305	84/447 (19%)
		Neur_chan_memb	398..667	CDD:280999	25/146 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100