Protein Alignment nAChRalpha2 and pHCl-1

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 106/482 - (21%)
• Similarity: 179/482 - (37%)
• Gaps: 117/482 - (24%)

  Fly    31 VLLLLCETVQANPDAKRLYD-------------------DLLSNYNRLIRPVSNNTDTVLVK-LG 75
            :|.||.|        |:.||                   |:.:|.|.. ||.:..|.||.|. |.
  Fly   340 ILDLLLE--------KKRYDKRLLPPVNDEDFCCGLQSPDMATNQNAR-RPHNRGTLTVNVNVLL 395

  Fly    76 LRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKW-DPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139
            |.|:...:.:||.::   ...|..:|.|.:.:: :.|.|..:..|: ..:.||.||.....:.|.
  Fly   396 LSLASPDESSLKYEV---EFLLNQQWNDPRLQYGNKSHYDFLNALH-HHDSIWTPDTYFIMHGDF 456

  Fly   140 EYVVTTMTKAI-LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHIS 203
            :..:..|..|: :...|.:.:........||:..:..||||...|.....|.:|:..||  |::
  Fly   457 KDPIIPMHFALRIFRNGTITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQI--KYV- 518

  Fly   204 QKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAE-----PYPDIFFNITLRRKTLF 263
            .|||:|.       ||: .||    :..:.|...:.....|.:     .|..:...:|..|...:
  Fly   519 WKNDEDT-------LRK-SPS----LTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAY 571

  Fly   264 YTVNLIIPCVGISYLSVLVFYL-----PADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPL 323
            |...:.||.:.:...|.:.|:|     ||    ::.:.::.:|:    |...|....||   ||:
  Fly   572 YFTTVFIPGIILVTSSFITFWLEWNAVPA----RVMIGVTTMLN----FFTTSNGFRST---LPV 625

  Fly   324 LGKYLLFTMLLVGLSV------------VITIIILNIHYRKPSTHKM--RPWIRSFFIKRLPKLL 374
            :..       |..::|            ::..:.:|...||...|.:  ||. .:...:||| .:
  Fly   626 VSN-------LTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPG-ENPVTQRLP-AV 681

  Fly   375 LMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHV 439
            |.|:...|...||:               .|....|.| .||::|.|       .|....:....
  Fly   682 LSRIGVILASPLAS---------------AAATPAMSM-MGGATPMS-------SGTPAASSSVA 723

  Fly   440 TTATNRFSGLVGALGGGLSTLSGYNGL 466
            |..|.|.:......|||:.....:.|:
  Fly   724 TPGTPRITDPEEFFGGGMRWQEAHGGI 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	56/245 (23%)
		LIC	47..544	CDD:273305	101/466 (22%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	59/253 (23%)
		Neur_chan_memb	578..>682	CDD:280999	25/123 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100