Protein Alignment nAChRalpha2 and Rdl

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 105/489 - (21%)
• Similarity: 185/489 - (37%)
• Gaps: 126/489 - (25%)

  Fly    10 PRPIALLAHIWRHCKPLCLLLVLLLLCE--------TVQA---------NPDAKRLYDDLLSNYN 57
            |.|...|..||       |.:.:.|:.:        ||||         :.:...:.|....:|:
  Fly    14 PLPRTPLLTIW-------LAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYD 71

  Fly    58 RLIRPVSNNTDTVLVKLG-----LRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVT 117
            :.:||   |.....|::|     |.:|.|.::.:.   .|.:.:....|.|.:..:  .:..||.
  Fly    72 KRVRP---NYGGPPVEVGVTMYVLSISSLSEVKMD---FTLDFYFRQFWTDPRLAY--RKRPGVE 128

  Fly   118 ELYVPSE---HIWLPDIVLYNNADGEY-VVTTMTKAI-LHYTGKVVWTPPAIFKSSCEIDVRYFP 177
            .|.|.||   :||:||....|.....: :.||..:.| :|::|.:..:......:||.::::|||
  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193

  Fly   178 FDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYP 242
            .|:|.|.::..|:.|  ...|:::..    :|....:|:......|  ::.:||......|  ..
  Fly   194 MDRQLCHIEIESFGY--TMRDIRYFW----RDGLSSVGMSSEVELP--QFRVLGHRQRATE--IN 248

  Fly   243 CCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYL-----PADSGEKIALCISILLS 302
            .....|..:...|...|...:|.:.:.||...|..:|.:.|:|     ||    ::||.::.:|:
  Fly   249 LTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPA----RVALGVTTVLT 309

  Fly   303 QTMFFLLISEIIPSTSLALPLLG------KYL--LFTMLLVGLSVVITIIILNIHYRKPSTHKMR 359
            .|       .::.||:.|||.:.      .||  .|.|:...|....|:
  Fly   310 MT-------TLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATV---------------- 351

  Fly   360 PWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRR 424
                .:..||:.    ||..    |.:|..||      ::.|..|  :|.........:|::...
  Fly   352 ----GYMAKRIQ----MRKQ----RFMAIQKI------AEQKKQQ--LDGANQQQANPNPNANVG 396

  Fly   425 MQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLS 458
            ..|.||.|              .|..|..|||::
  Fly   397 GPGGVGVG--------------PGGPGGPGGGVN 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	49/228 (21%)
		LIC	47..544	CDD:273305	94/435 (22%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	43/197 (22%)
		Neur_chan_memb	274..588	CDD:397193	44/204 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100