Protein Alignment nAChRalpha2 and lgc-28

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001022053.1
• Gene: lgc-28 / 3565225
• WormBaseID: WBGene00044301
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 400
• Identity: 76/400 - (19%)
• Similarity: 144/400 - (36%)
• Gaps: 106/400 - (26%)

  Fly    44 DAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKW 108
            |..:.:||.:        |:..:....|:.| |.:..:.|:..:..:|...:.....|.|.:..|
 Worm    39 DITKRFDDTM--------PIKKDGYLQLIPL-LHVDHIHDIQDEQGVLKMALTFTFTWMDERLMW 94

  Fly   109 DPSEYGGVTELYVPSEH------IWLP--------------------DIVLYNNADGEYVVTTMT 147
            :||.|.|: ..:..:.|      .|.|                    |:.:|.::.|  :|.|..
 Worm    95 NPSNYSGI-RTFSTTRHEMWRKKFWTPTLMMTDVPNSRRPSDVFKPFDMDIYISSSG--MVRTSA 156

  Fly   148 KAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCF-----------MKFGSWTYDGDQIDLKH 201
            :.:|        |.|      |......:|.|.:.|.           .:|..|   |.....::
 Worm   157 RMML--------TIP------CRTGFGSYPNDYKNCTFTLMSPYYADQFRFAQW---GGAEFTRY 204

  Fly   202 I--SQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYP-CCAEPYPDIFFNITLRRKTLF 263
            :  |:..|..:...|.||.|.||..:..:::    :...|:.| .|...|.   :|:.|:|...|
 Worm   205 LMSSRVTDVLDFQLINIDTRNYYMFLGSEVV----DDFSKFKPRHCRSFYR---YNLVLKRVNKF 262

  Fly   264 YTVNLIIPCVGISYLSVLVFYLPADSGEKIALCI-SILLSQTMFFLLISEIIPSTSLALPLLGKY 327
            .:|.||.|...|:....:..:||...|   .:|. |.|:.:|:|...:.:::|.....:|::.
 Worm   263 VSVQLIAPISVIAVFLAISGFLPHFYG---LVCAGSALVYETIFTYDVEQVLPKDYSGMPMIA-- 322

  Fly   328 LLFTMLLVGLSVVITIIILNIHYRKPSTHKMRP-------------------WIRSF-----FIK 368
            :|...|.....|::...:.:|:.|..:.....|                   |:..|     |::
 Worm   323 ILLCFLFAETIVLLAWKVFSINTRSHTVFTAFPEYFDDEITSKKEKLLKFVIWVDKFLMVALFVQ 387

  Fly   369 RLPKLLLMRV 378
            ....:.|.|:
 Worm   388 SFVVMYLARI 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	49/258 (19%)
		LIC	47..544	CDD:273305	75/396 (19%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	25/141 (18%)
		LIC	67..>329	CDD:273305	59/293 (20%)
		Cys-loop	164..178	CDD:349787	3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810