Protein Alignment nAChRalpha2 and lgc-8

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001023533.2
• Gene: lgc-8 / 3564870
• WormBaseID: WBGene00013338
• Length: 438
• Species: Caenorhabditis elegans
• Alignment Length: 380
• Identity: 98/380 - (25%)
• Similarity: 187/380 - (49%)
• Gaps: 33/380 - (8%)

  Fly    29 LLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTT 93
            :|:|..|.| :.....:::|.|.|:..|:..||||.|..||:.:.:.:.....:.|:..::.:..
 Worm    13 VLILWNLLE-IDGITVSEQLKDVLMEGYDSSIRPVINERDTLFINISINSMSFLTLDPAEETINF 76

  Fly    94 NVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAI-LHYTGKV 157
            :.....:|:|....|:.|:| .:|.|.:....:|.||..:..:.|..|::.|..:.: :.|.|.|
 Worm    77 SGEFILQWKDEFLFWNKSDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIETSERYVSVKYDGTV 140

  Fly   158 VWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHIS-------QKNDKDNKVEIG 215
            .....|:|.:.|::::..||:|||||.:|.|.|:|     .:|.::       ::|:...|
 Worm   141 RQNIYAVFTNLCDMNINEFPYDQQTCMIKMGPWSY-----TMKEVTCIVGGDIERNETTGK---- 196

  Fly   216 IDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSV 280
                 :..:.|||..|:.:...|...|.....:.::.|.:|::|:..||...|:||...|:.:.:
 Worm   197 -----FQGNSEWDFEGIVSSVGETEDPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCI 256

  Fly   281 LVFYLP-ADSG---EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVI 341
            ...:.| |:.|   |::.|.|:.|||..:...:::..:|.|| .|||||.::|..:.:|.:.|:.
 Worm   257 FGLFTPTANHGLREERVNLGITTLLSSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLF 320

  Fly   342 TIIILNIHYRKPSTHKMRPWIRSFFIKRL---PKLLLMRVPKDLLRDLAANKINY 393
            .:::|.:|.| ..|.:.||.....:|.|:   .|.|...:.|...:...|.:|:|
 Worm   321 AVLVLTLHQR-AHTREWRPPAWMLWILRMTGSSKFLSRNITKIRHKSSTAERIHY 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	54/226 (24%)
		LIC	47..544	CDD:273305	94/362 (26%)
lgc-8	NP_001023533.2	Neur_chan_LBD	29..237	CDD:280998	54/222 (24%)
		Neur_chan_memb	244..>348	CDD:280999	31/105 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810