Protein Alignment nAChRalpha2 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 204/580 - (35%)
• Similarity: 304/580 - (52%)
• Gaps: 102/580 - (17%)

  Fly    10 PRPIALLAHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKL 74
            |.|.:|...:        ||:.|.::.|:.| .|..|||.:.|||.||.|.|||:|.::.:.||.
  Fly     4 PLPASLSLFV--------LLIFLAIIKESCQ-GPHEKRLLNHLLSTYNTLERPVANESEPLEVKF 59

  Fly    75 GLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139
            ||.|.|:||::.|:||||||.||..||.|:..:|:.:|||||.:|.:....:|.||:::||:||.
  Fly    60 GLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADE 124

  Fly   140 EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQ 204
            .:..|..|..::.:.|..::.||.||||:|:||:.:||||.|.|.||||||||||:|:||    .
  Fly   125 GFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL----V 185

  Fly   205 KNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLI 269
            .|.:|     |.||.::..:.||.:|.:|.:::...|.||.|||.||.|.|.:||:||:|..|||
  Fly   186 LNSED-----GGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLI 245

  Fly   270 IPCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPST----------------- 317
            :|||.||.:::|.|.||.|||||:.|.::||||.|:|..|::|.:|:|
  Fly   246 VPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTV 310

  Fly   318 ------------SLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRL 370
                        |.|:||||.|....|.:|..|||:|:::||.|:|....|:|.|||:|.|::.|
  Fly   311 FLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWL 375

  Fly   371 PKLLLMRVPKDLLRDLAANKINYGLKFS-KTKFGQALMDEMQMNSGGSS---------PDSLRRM 425
            |.:|.|..|              |.|.: ||......|.|:::....|.         .|..|
  Fly   376 PWILRMGRP--------------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFR-- 424

  Fly   426 QGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFEL 490
                              :..||...|:|...|.     |.|:.   :::..:.:....|   :|
  Fly   425 ------------------HTISGSQTAIGSSASF-----GRPTT---VEEHHTAIGCNHK---DL 460

  Fly   491 EKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSL 550
            ...:..:.||...|::.|:......||.|.|||:||..|.:|.:.:::.|..:|..||.:
  Fly   461 HLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	100/218 (46%)
		LIC	47..544	CDD:455710	191/535 (36%)
		Cys-loop	169..183	CDD:349832	8/13 (62%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	199/568 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	85/189 (45%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)