DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and nAChRbeta3

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_525098.1 Gene:nAChRbeta3 / 33228 FlyBaseID:FBgn0031261 Length:441 Species:Drosophila melanogaster


Alignment Length:543 Identity:122/543 - (22%)
Similarity:219/543 - (40%) Gaps:154/543 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PLCLLLVLLLLCETVQANPDA--------------KRLYDDLLSNYNRLIRPVSNNTDT-VLVKL 74
            ||.|.:::.:|...:.:.|.|              .||:..|.:||:..::||...|.| |.:::
  Fly    17 PLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM 81

  Fly    75 GLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG 139
            .:....:.:||.|   |||:.||...|:|.:..|.||:|..:|::.:.|..:|.|.|.|:|..:|
  Fly    82 VVTYIDIDELNGK---LTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEG 143

  Fly   140 EYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQ 204
            ..:..  |:..|.:.|...|.|||::.:.||:::..:|.|:|:|.:|.|||       .||.:..
  Fly   144 GLMAE--TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-------GLKVVLP 199

  Fly   205 KN--------DKDNKVEIGIDLREYYPSVEWDILGVPAERH---EKYYPCCAEPYPDIFFNITLR 258
            :|        |.|:.|:          |.||:|  |.:..|   :.||     .|.:  :.:|.:
  Fly   200 ENGTARGESLDHDDLVQ----------SPEWEI--VDSRAHFVSQDYY-----GYME--YTLTAQ 245

  Fly   259 RKTLFYTVNLIIPCVGISYLSVLVFYLPAD-SGEKIALCISILLSQTMFFLLISEIIPSTSLALP 322
            |::..||..:..|...|..|::..|:||.. .||||.:...:::....|.:..::::|..|...|
  Fly   246 RRSSMYTAVIYTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTP 310

  Fly   323 LLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLA 387
            |:..:...::|.:.:|.::.:::|   |.....||.|                            
  Fly   311 LVVIFYSTSLLYLSVSTIVEVLVL---YLATGKHKRR---------------------------- 344

  Fly   388 ANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGA 452
                                          .|::||::                       |.|.
  Fly   345 ------------------------------LPEALRKL-----------------------LHGH 356

  Fly   453 LGGGLSTLSGYNGLPSVLSGLDDSLSD-VAARKKYPF-ELEKAIHNVMFIQHHMQRQDEFNAEDQ 515
            ||..|        |.||.|...:|.:: .....::|: |.::...:.:.|.|  .......|...
  Fly   357 LGTWL--------LLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINH--TEVPGAKANQF 411

  Fly   516 DWGFVAMVMDRLFLWLFMIASLV 538
            ||..:|..:||:....|.:|.|:
  Fly   412 DWALLATAVDRISFVSFSLAFLI 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 67/244 (27%)
LIC 47..544 CDD:273305 116/507 (23%)
nAChRbeta3NP_525098.1 LIC 39..437 CDD:273305 116/521 (22%)
Neur_chan_LBD 52..247 CDD:280998 65/225 (29%)
Neur_chan_memb 255..434 CDD:280999 47/272 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.910

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