Protein Alignment nAChRalpha2 and CG8916

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 316
• Identity: 63/316 - (19%)
• Similarity: 146/316 - (46%)
• Gaps: 38/316 - (12%)

  Fly    48 LYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSE 112
            :.::||..|.:...|........:|:..:.:..:..::..|...:.:.:....|:|.:..:.
  Fly   111 ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFK--- 172

  Fly   113 YGGVTELYVP---SEHIWLPDIVLYNNADGE-YVVTTMTKAI-LHYTGKVVWTPPAIFKSSCEID 172
             |.:..|.:.   .:.||.||...||....: :::|...|.: |...|.::::.....|::|.::
  Fly   173 -GPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPME 236

  Fly   173 VRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEI--GIDLREYYPSVEWDILGVPAE 235
            ::.||.|:|:|.:..||:.|...|:    |.:..::|:.|..  |:.|.::      |::.:
  Fly   237 LQNFPMDRQSCPLVIGSYGYINQQL----IYEWKNQDDAVSFVPGMTLNQF------DLISM--- 288

  Fly   236 RHEKYYPCCAE-PYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPAD-SGEKIALCIS 298
            .|..:.....| .:..:.....|:|.|.::.:.:.:||:.|..||.:.|::..: :.::::||::
  Fly   289 MHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVT 353

  Fly   299 ILLSQTMFFLLISEIIPSTSLALPLLGKY---LLFTMLLVGLSVVITII-ILNIHY 350
            .:|:       :|.|...:...||.: ||   |.:.:|:..|..:.|:: ...:||
  Fly   354 SVLT-------LSTISLDSRTDLPKV-KYATALDWFLLMSFLYCIATLLEFAGVHY 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	42/222 (19%)
		LIC	47..544	CDD:455710	63/316 (20%)
		Cys-loop	169..183	CDD:349832	5/13 (38%)
CG8916	NP_573090.3	LIC	92..598	CDD:455710	63/316 (20%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	36/198 (18%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)