DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and nAChRalpha3

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster


Alignment Length:786 Identity:312/786 - (39%)
Similarity:408/786 - (51%) Gaps:243/786 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILT 92
            ::|||..:..:. |||||||||||||||||:|:|||.|.||.:.|::.|:||||||:|||:||:|
  Fly    10 MILVLSFISSST-ANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMT 73

  Fly    93 TNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKV 157
            ||:|:|..|.|:|.||:|.|||||..|:|||:|||.|||||||||||.:.||..|||.|:|||:|
  Fly    74 TNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRV 138

  Fly   158 VWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYY 222
            .|.||||:||||||||.|||||:|||.||||||||||.|:||:||.:.|. .|.||:|:||.|:|
  Fly   139 EWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNG-TNVVEVGVDLSEFY 202

  Fly   223 PSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPA 287
            .|||||||.|||.|:||:|.||.|||.||.||||:|||||||||||||||:|||:|::||||||:
  Fly   203 TSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPS 267

  Fly   288 DSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRK 352
            |||||::|.||||||.|:||||::||||.|||.:|||||::||||:|...|:.:|:::||||:|.
  Fly   268 DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRS 332

  Fly   353 PSTHKMRPWIRSFFIKRLPKLLLMRVP-----------KDL---------LRD--------LAAN 389
            |.||.|.||:|:.||.:||:.|:||.|           :.|         |||        :|.:
  Fly   333 PQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALS 397

  Fly   390 KINYGLKFSKTKFG---------QALMDEMQMNSGGS---------------------------- 417
            ::::..|.:.....         ..||||..|..||.                            
  Fly   398 RMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSS 462

  Fly   418 ----------------------SPDSLRRM------QGRVGAGGCNG------------------ 436
                                  :|...|:|      .|:.|:|..||                  
  Fly   463 LIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQ 527

  Fly   437 -----------------MHVTTATNRF----------------------------SGLV------ 450
                             .|.:|.|:..                            ||.:      
  Fly   528 QSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGM 592

  Fly   451 -------------------------------------------------GALGGGLST------- 459
                                                             .|..||.||       
  Fly   593 GAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAA 657

  Fly   460 ----LSGYNGLPSVLSGLDDSL---------------SDVAARKKYPFELEKAIHNVMFIQHHMQ 505
                .:|....|...:|:.|.|               .:|..|.....||.||:..|.:|....:
  Fly   658 AAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTR 722

  Fly   506 RQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSLYDDTKAIDVQLSDVAKQIYN 570
            :::|.....:||.:||||:||||||:|.||.:|||..|:.:||:|||....||::||::|    :
  Fly   723 KEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPIDIKLSEIA----S 783

  Fly   571 LTEKKN 576
            .|.|.|
  Fly   784 TTAKPN 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 152/218 (70%)
LIC 47..544 CDD:273305 289/733 (39%)
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 149/215 (69%)
Neur_chan_memb 248..>359 CDD:280999 70/110 (64%)
Neur_chan_memb <683..760 CDD:280999 27/76 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2065
eggNOG 1 0.900 - - E1_KOG3645
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I1461
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm6399
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
98.970

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