Protein Alignment nAChRalpha2 and CG6927

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 130/590 - (22%)
• Similarity: 212/590 - (35%)
• Gaps: 170/590 - (28%)

  Fly    28 LLLVLLLLCETVQA---NPDAKRLYD-DLLS------------NYNRLIRPVSNNTDTVLVKLGL 76
            |::.:||.|....|   :.|...|.| |.||            .|:||.||::.:      :.|.
  Fly     5 LIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYS------ETGQ 63

  Fly    77 RLSQLIDLNLKDQI-LTTNVWLEHEWQDHKFK---------WDPS-EYGGVT----ELYVPSEH- 125
            ||.  :|:.::..| ...|:    |..|.:||         .||. .:..|:    :..:..||
  Fly    64 RLP--VDVYMRAYIYFMQNL----EAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHL 122

  Fly   126 ---IWLPDIVLYN------------------NADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSC 169
               :|:|.|.|.|                  :.||..:|:...||.|:                |
  Fly   123 RNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLY----------------C 171

  Fly   170 EIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEW-DILGVP 233
            .::::.||||:|.|.....||.|:..::.| |..||  :....:..:.|.|:.....| :...:.
  Fly   172 WLNLKKFPFDEQHCSTVLESWMYNTSELVL-HWEQK--RPITYDGALHLTEFVLQRSWSNETVIN 233

  Fly   234 AERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSG-EKIALCI 297
            |:..:..:...|..|..:.|.:.|.|...||.::..:|.:.|..:|.:.|:|.||.. .:|.|..
  Fly   234 ADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGT 298

  Fly   298 SILLSQTMFFLLIS---EIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMR 359
            |.||:   |..|.|   :.:|..|........:|..|:.:.| |:|....:..|..||
  Fly   299 STLLT---FITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFG-SMVEFAFVNTIWRRK------- 352

  Fly   360 PWIRSFFIKRL--PKLLLMRVPKDLLR-------------------DLAA-------NKINYGLK 396
               :|..:|:|  ..:|...:..:|||                   |..:       |.:...|.
  Fly   353 ---KSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLP 414

  Fly   397 FSKTKFGQAL--------MDEMQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGAL 453
            .:..|.||.|        :.:|.:|...|:..|:...|........:.....|..||...
  Fly   415 ITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTES----- 474

  Fly   454 GGGLS--TLSGYNGL-PSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQ 515
            .|...  .|||:..| |..::...||      |.::.|.|...:.|:.|
  Fly   475 AGHQEEIDLSGWTTLTPQEIAMWIDS------RARFVFPLSFLVFNLFF---------------- 517

  Fly   516 DWGFV 520
             |.||
  Fly   518 -WTFV 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	60/269 (22%)
		LIC	47..544	CDD:455710	124/568 (22%)
		Cys-loop	169..183	CDD:349832	6/13 (46%)
CG6927	NP_572194.1	LIC	3..520	CDD:455710	128/587 (22%)