Protein Alignment nAChRalpha2 and chrna1

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_571520.1
• Gene: chrna1 / 30725
• ZFINID: ZDB-GENE-980526-137
• Length: 456
• Species: Danio rerio
• Alignment Length: 528
• Identity: 193/528 - (36%)
• Similarity: 285/528 - (53%)
• Gaps: 103/528 - (19%)

  Fly    26 LCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQI 90
            :.:|.:|..|......:.|..||...|.:.||:::||||:..|.|:|.:||:|.|||.::..:||
Zfish     5 ILILPILPYLYGPAVCSEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQLISVDEVNQI 69

  Fly    91 LTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTG 155
            :|:||.|:.:|:|...:|:|.:|||:.::.:||..:|.||:||||||||::.:...||.:|.:||
Zfish    70 VTSNVRLKQQWKDVHLQWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDFAIVHETKVLLEHTG 134

  Fly   156 KVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLRE 220
            .:.|||||||||.|||.|.:||||.|.|.||.|:|||||:.:.:...|.:.|..|.:|.|
Zfish   135 MITWTPPAIFKSYCEIVVLHFPFDLQNCSMKLGTWTYDGNLVIINPDSDRPDLSNFMESG----- 194

  Fly   221 YYPSVEWDILGVPAERHEKYYPCCAE-PYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFY 284
                 ||.:....:.:|..||.||.: ||.||.::..|.|..|::.||:||||:..|:|:.||||
Zfish   195 -----EWVMKDYRSWKHWVYYACCPDTPYLDITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFY 254

  Fly   285 LPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIH 349
            ||.|||||:.|.||:|||.|:|.|:|.|:|||||.|:||:|||:||||:.|..|::||:|::|.|
Zfish   255 LPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTH 319

  Fly   350 YRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNS 414
            :|.||||.|..|:|..||..:|.::.                     ||..|
Zfish   320 HRSPSTHIMPAWVRKIFIDTIPNMMF---------------------FSTMK------------- 350

  Fly   415 GGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSD 479
                ..|..|.:.|:                                    .|:     |..:||
Zfish   351 ----RPSQERQEKRL------------------------------------FPA-----DFDISD 370

  Fly   480 VAAR------------KKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLF 532
            ::.:            .|.| ::..||..|.:|...|:..:|.|...::|.|||||:|.:.|.:|
Zfish   371 ISGKPMPASVTYHSPITKNP-DVRSAIEGVKYIADTMKSDEESNNAAEEWKFVAMVLDHILLCVF 434

  Fly   533 MIASLVGT 540
            |...::||
Zfish   435 MAVCIIGT 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	95/219 (43%)
		LIC	47..544	CDD:455710	189/507 (37%)
		Cys-loop	169..183	CDD:349832	9/13 (69%)
chrna1	NP_571520.1	LIC	21..447	CDD:455710	190/512 (37%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	95/218 (44%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)