DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and Chrne

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_017452660.1	Gene:	Chrne / 29422	RGDID:	2353	Length:	547	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	167/544 - (30%)
Similarity:	260/544 - (47%)	Gaps:	109/544 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDH 104
            |...:...||..|..||:...|||....|||.:.|.:.|:.||.||.|::.|||:||:..||||:
  Rat    72 QGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDY 136

  Fly   105 KFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSC 169
            :..:...::.||..|.|||||:|||:|||.||.||::.|......:::..|.|.|.||||::|:|
  Rat   137 RLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTC 201

  Fly   170 EIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKV-EIGIDLREYYPSVEWDILGVP 233
            .::|.|||||.|.|.:.|.|.||:.::::.  |...:|..|.: :|.||...:..:.||.|
  Rat   202 AVEVTYFPFDWQNCSLIFRSQTYNAEEVEF--IFAVDDDGNAINKIDIDTAAFTENGEWAI---- 260

  Fly   234 AERHEKYYPCCAEPY----------PDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPAD 288
                 .|.|.....|          .|:.:.:.:|||.|||.:|:|:|||.||.|.:|.::|||.
  Rat   261 -----DYCPGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQ 320

  Fly   289 S-GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRK 352
            : |:|..:.|::||:||:|..||::.||.|||::||||:||:|.|::..|.|:..:|:||:..|.
  Rat   321 AGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRT 385

  Fly   353 PSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGS 417
            |:||...|.:|...::.||:||.:..|.:                               :.|.:
  Rat   386 PTTHATSPRLRQILLELLPRLLGLSPPPE-------------------------------DPGAA 419

  Fly   418 SPDS---------------LRRMQGRVGAGGCNGMHVT-TATNRFSGLVGALGGGLSTLSGYNGL 466
            ||..               |::.:..:...|....|.| ||
  Rat   420 SPARRASSVGILLRAEELILKKPRSELVFEGQRHRHGTWTA------------------------ 460

  Fly   467 PSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWL 531
                :.|..:||..|.      |:...:..|.|:....:.|:....|..||..:...:|.:..|.
  Rat   461 ----AALCQNLSAAAP------EVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWA 515

  Fly   532 FMIASLVG-TFVILG----EAPSL 550
            .::...|| |.:.||    :.|.|
  Rat   516 ALVLFSVGSTLIFLGGYFNQVPDL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	83/229 (36%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	162/525 (31%)
Chrne	XP_017452660.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810