Protein Alignment nAChRalpha2 and HTR3E

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001243543.1
• Gene: HTR3E / 285242
• HGNCID: 24005
• Length: 482
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 93/358 - (25%)
• Similarity: 162/358 - (45%)
• Gaps: 65/358 - (18%)

  Fly    41 ANPDAKRLYDDLLSNYNRL-IRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDH 104
            |:|.|      |.|.:||. .|||:|.:....|.:...:|.::|:          ||      |:
Human    55 ADPTA------LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV----------VW------DN 97

  Fly   105 KF-KWDPSEYGGVTELYVPSEHIWLPDIVL----YNNADGEYV------------------VTTM 146
            .| .|:|.|..|:|::.:.::::|||||.:    .:.|....|                  |...
Human    98 PFISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKT 162

  Fly   147 TKAILHYT---GKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDL---KHISQK 205
            .|.:..|.   |::.:..|....|.|.:|:.|||||||.|.:.|.|:.|..|.:.|   |.:.:.
Human   163 PKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEI 227

  Fly   206 NDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLII 270
            .|....:     |:.:   .||::||:  .:...........|..|.|.:.:||:...|.:||::
Human   228 TDASRNI-----LQTH---GEWELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLV 282

  Fly   271 PCVGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLV 335
            |...:..:..|.||||..||.::...|::||...:|.|::|:::|::  ..||:|.|....:.|:
Human   283 PSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLM 345

  Fly   336 GLSVVITIIILN-IHYRKPSTHKMRPWIRSFFI 367
            ..|::.||.|.: :|........:..|:.|..:
Human   346 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLL 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	61/248 (25%)
		LIC	47..544	CDD:273305	90/352 (26%)
HTR3E	NP_001243543.1	Neur_chan_LBD	70..273	CDD:280998	56/228 (25%)
		Neur_chan_memb	280..>379	CDD:280999	28/101 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810