Protein Alignment nAChRalpha2 and pbo-6

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001294833.1
• Gene: pbo-6 / 24104421
• WormBaseID: WBGene00017375
• Length: 422
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 103/371 - (27%)
• Similarity: 181/371 - (48%)
• Gaps: 51/371 - (13%)

  Fly    27 CLLLVLLLLCETV---------QANPDAKRLYDDLLSNYNRLIRP-----VSNNTDTVLVKLGLR 77
            |..|.:.:...||         |....:.||...||..:|:...|     :|:|.:.|.: :|:.
 Worm     3 CSFLTIFIFITTVTVGVAEFSEQYQGSSSRLTRHLLEKHNKCSPPDGRVDISHNIELVHI-IGIN 66

  Fly    78 LSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYV 142
                 :||...|:|   |::..:|.|....|...|:.|:...::|...||:|||:::|..:.:.:
 Worm    67 -----ELNQNMQVL---VYIVQQWTDASLSWKVEEFRGIKHTWLPEHSIWIPDIIVFNTLEHKML 123

  Fly   143 VTTMTKAI-LHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKN 206
            :..:...| :.|||:|.:..|||:...|:|.:..||||.|.|.::|.||.||.|:| |.:.|.|.
 Worm   124 LEAVRSPIKVSYTGEVTYAYPAIYTVLCQIGIATFPFDDQVCKIRFASWAYDEDKI-LLNASHKP 187

  Fly   207 DKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIP 271
                      .|:.|.|:.||.:..|...|.|  |........:|.:.|.:.||..:|.::|::|
 Worm   188 ----------LLKNYSPNEEWALQDVDMARKE--YEHEETVVSEIIYYIKVARKPFYYLISLVVP 240

  Fly   272 CVGISYLSV----LVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTM 332
            ...|..||:    ..|....:..|:..|.::.:||..:..|:::|.:|.:|..:|||..|:.|.:
 Worm   241 SYIICVLSIAGLFARFSTKHERQERFTLGVTAILSMAVLSLVVTEKVPHSSENVPLLIVYMHFII 305

  Fly   333 LLVGLSVVITIIILNIHYRKPSTHKMRP--WIRSFFIKRLPKLLLM 376
            ::|.::.::|..::.:|.:...||.:.|  |||        |:||:
 Worm   306 VMVTIATILTSTVMRVHAKGFRTHFLSPPNWIR--------KVLLI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	66/224 (29%)
		LIC	47..544	CDD:273305	98/342 (29%)
pbo-6	NP_001294833.1	Neur_chan_LBD	31..230	CDD:280998	65/220 (30%)
		Neur_chan_memb	264..>342	CDD:280999	23/85 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810