DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha2 and HTR3D

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001157118.1	Gene:	HTR3D / 200909	HGNCID:	24004	Length:	454	Species:	Homo sapiens

Alignment Length:	340	Identity:	69/340 - (20%)
Similarity:	133/340 - (39%)	Gaps:	70/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVP 122
            :.|.||:|.:....|.:...||.:  .|...:|.|.|......|.:...:|:|.|.||:.:..:.
Human    51 KAIGPVTNYSVATHVNISFTLSAI--WNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMA 113

  Fly   123 SEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVV----------WTP---PAIFKSSCEIDVR 174
            :|::||.|:.:..:.|........:.:|:..|...:          |||   |::.::.
Human   114 TENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRAR------ 172

  Fly   175 YFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEK 239
                          :|........:.|.:                .:....||.:||:  ::...
Human   173 --------------AWRRMSRSFQIHHRT----------------SFRTRREWVLLGI--QKRTI 205

  Fly   240 YYPCCAEPYPDIFFNITLRR--KTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISILLS 302
            ........|....|::.:||  :...|.||.::|...:..:..|.||||.:||......:::||.
Human   206 KVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLG 270

  Fly   303 QTMFFLLISEIIPST------SLALPL--------LGKYLLFTMLLVGLSVVITIIILN-IHYRK 352
            .::|.|::::::|:|      ||..||        .|.|....:.|:..|::.||.|.: :|...
Human   271 YSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVAT 335

  Fly   353 PSTHKMRPWIRSFFI 367
            .....:..|:.|..:
Human   336 TQPLPLPRWLHSLLL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	38/219 (17%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	69/340 (20%)
HTR3D	NP_001157118.1	Neur_chan_LBD	55..>130	CDD:280998	20/76 (26%)
		LIC	92..452	CDD:273305	58/297 (20%)
		Neur_chan_memb	237..>351	CDD:280999	28/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810