Protein Alignment nAChRalpha2 and acr-23

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_504024.2
• Gene: acr-23 / 191606
• WormBaseID: WBGene00000062
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 144/583 - (24%)
• Similarity: 232/583 - (39%)
• Gaps: 141/583 - (24%)

  Fly    29 LLVLLLLCETVQANPDAKRLYD---DLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQI 90
            |:.:..|...:..|||....|:   :::.||.:.:.|.......:.|.|.|:|.|:|.:|...|.
 Worm     8 LIFISQLALGLSNNPDIPIQYELANNIMENYQKGLIPKVRKGSPINVTLSLQLYQIIQVNEPQQY 72

  Fly    91 LTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHY-- 153
            |..|.|....|.|....|||||:...||:....:.|||||..|||:.:.:   .:.:|.:.|.
 Worm    73 LLLNAWAVERWVDQMLGWDPSEFDNETEIMARHDDIWLPDTTLYNSLEMD---DSASKKLTHVKL 134

  Fly   154 --TGK-----VVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNK 211
              .||     |....|.|:|.||.::::|||||.|||.|.||||::|...||....:..|..
 Worm   135 TTLGKNQGAMVELLYPTIYKISCLLNLKYFPFDTQTCRMTFGSWSFDNSLIDYFPRTFTNGP--- 196

  Fly   212 VEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGIS 276
                |.|..:..:..|.:||....|.||.|.||...|..:.:::.::||.|:|.:|||.|...|:
 Worm   197 ----IGLANFLENDAWSVLGTKVNREEKKYTCCPVNYTLLHYDVVIQRKPLYYVLNLIAPTAVIT 257

  Fly   277 YLSVLVFYLPAD---------------SGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGK 326
            ::|::.|:...:               ..|||.|.|:.|||.::...::|:.:||||..:||:..
 Worm   258 FISIIGFFTSVNPFTNFCNVSSSVHDLRQEKITLGITTLLSMSIMIFMVSDKMPSTSTCVPLIAL 322

  Fly   327 Y--LLFTMLLVGLSVVITIIILN----------------IH------------------------ 349
            :  |:.|::.||.....::|.:.                .|
 Worm   323 FYTLMITIISVGTLAASSVIFVQKLGSIGNPPASKTMKWTHRIAPFVLIQMPLVMKQAYAKRAKE 387

  Fly   350 --YRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFG---QALMDE 409
              :||..:.|...|.:.:.:.|....|:..||.      .|.|.|....|.....|   ...|.|
 Worm   388 EKHRKRMSRKNSMWTKVYHLARDHSKLMETVPD------GAVKFNQISDFKNNDIGNMESPRMAE 446

  Fly   410 MQMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLD 474
            .|.:...::|         :.......:|:..               |:.::..|.:.|||...:
 Worm   447 SQTSETFAAP---------MDTSFTESLHIPE---------------LNRVASSNSIQSVLKPTE 487

  Fly   475 DSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASL 537
            ..|:....|                           |..:.:|.:||.|::|:||..|.|..|
 Worm   488 IQLTPYCTR---------------------------NIVELEWDWVAAVLERVFLIFFTICFL 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	74/230 (32%)
		LIC	47..544	CDD:273305	139/565 (25%)
acr-23	NP_504024.2	Neur_chan_LBD	27..242	CDD:280998	72/224 (32%)
		Neur_chan_memb	249..529	CDD:280999	63/332 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910