DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and acr-18

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_506868.2	Gene:	acr-18 / 191604	WormBaseID:	WBGene00000057	Length:	510	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	150/567 - (26%)
Similarity:	259/567 - (45%)	Gaps:	108/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLCLLLVLLLLCETVQANPDAKR-----LYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDL 84
            |..|:|..:|....|.|.....|     ||:.|..:|.:.||||.|.::::.|::...|.|::.:
Worm     5 PCFLILWQILSSHRVHATSHPARTPMRNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKV 69

  Fly    85 NLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTM-TK 148
            :.:|||:....|||..|.|....|||.::|.::.::||:..||.||:::||||:.......| |.
Worm    70 DERDQIVNIYCWLELYWIDETLTWDPKKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETN 134

  Fly   149 AILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE 213
            ||:..||:|:.....|...||.::::.||||||.||:.|.||:.||.::||. .:.|.|
Worm   135 AIVDNTGRVMLFRSMITDISCNLNLQQFPFDQQICFVTFASWSMDGSKLDLS-ATPKTD------ 192

  Fly   214 IGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYL 278
               :|..|..:.||.:.....:.::|.|.||..|:||:.:.:.|||...:|..:|:||...|:.:
Worm   193 ---NLELYIRNTEWGLTDFRVKIYQKIYDCCPHPFPDVTYFMVLRRSPSYYIFSLVIPSAFITVV 254

  Fly   279 SVLVFYLP----ADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSV 339
            :::.|:.|    .::.||::|.::.|||..:..:::|:.:|:||..:||:|||.:..:.|:.::.
Worm   255 TIVGFFTPHSTTGENTEKVSLGVTALLSMAIIMMMVSDEVPATSEVIPLIGKYYIGLIFLIFMAA 319

  Fly   340 VITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANK-INYGLKFSKTKFG 403
            ..|.:.|:...|..|..::.|.:|.||..:                :|||. |::...|
Worm   320 FTTTLTLSYQMRGNSGQEVDPRVRDFFFYQ----------------IAANPCISWAFSF------ 362

  Fly   404 QALMDEMQMNSGGSSPDSLRRMQGRV-------GAGGCNG-----MHVTTATNRFSGLVGALGGG 456
                         ..|..|.|...|.       ||...||     :|..|.......:....|||
Worm   363 -------------QLPKKLLRSDHRKQSFFFTNGAAHVNGYSKGALHPNTPPAHIVKMEEITGGG 414

  Fly   457 -------------LSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQD 508
                         .|||     |.|.|..:...|.|:    |.....|:.:..:.|
Worm   415 SVKSFVMSQESAATSTL-----LTSSLMKIKVVLDDM----KASIHAERELKRIKF--------- 461

  Fly   509 EFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILG--EAPSLYDD 553
                   :|..|..::||..::.:::.::....|:|.  :.|.:.:|
Worm   462 -------EWQQVTRLIDRCIMFSYILITIAFAMVMLASRDPPIVLND 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	76/224 (34%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	141/532 (27%)
acr-18	NP_506868.2	Neur_chan_LBD	33..237	CDD:280998	75/213 (35%)
acr-18	NP_506868.2	Neur_chan_memb	244..486	CDD:280999	63/301 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810