Protein Alignment nAChRalpha2 and lev-8

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_509932.2
• Gene: lev-8 / 191600
• WormBaseID: WBGene00002975
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 565
• Identity: 187/565 - (33%)
• Similarity: 314/565 - (55%)
• Gaps: 82/565 - (14%)

  Fly    16 LAHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQ 80
            ::||:       ||::.:|...|:.||....:|.::||::||:.:|||.|.:|.:.||.|..|.:
 Worm     7 ISHIF-------LLVIFILHIVTINANKHVSQLLENLLTDYNKAVRPVHNASDALKVKFGANLCR 64

  Fly    81 LIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTT 145
            |||::..:|:|||::|||.:|.|.|..|:|:::|||..:::||:.||:||||||||||||..:|.
 Worm    65 LIDVDEVNQVLTTSLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNADGEPHITI 129

  Fly   146 MTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDL-------KHIS 203
            .:.|.:.:.|:|||.||:|:||.|.|:::|||:|.|||.||||.|:.||:.:||       ..|.
 Worm   130 TSLAKIDHHGRVVWQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQIPVDVDDIP 194

  Fly   204 QKNDKDNKVEI-----GIDLREYYPSVEWDILGVPAERHEKYYP-CCAEP-YPDIFFNITLRRKT 261
            |...:|:.||.     |:.|..|:.|.|||:|...:.|:.:.|| ||.:. |.||.:.|.:|||.
 Worm   195 QVKRQDDGVEFLYLEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRKA 259

  Fly   262 LFYTVNLIIPCVGISYLSVLVF-YLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLG 325
            :|:||.|.|||:.|:.::..|| .||.:  .|:...||:|::.::|:|::.::||.|||:|.|:|
 Worm   260 IFFTVTLTIPCMLIANVTPFVFLILPNE--HKMTYSISVLVAFSVFYLVLIDLIPPTSLSLSLIG 322

  Fly   326 KYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANK 390
            .|||||:|:|.:|::::::.:|::.::..:..|..|.|..|::||||||.:   |.|...|..::
 Worm   323 IYLLFTLLMVSVSIILSVVTINMYRKQAFSSGMSHWQRWLFVQRLPKLLRL---KTLEHTLGPDE 384

  Fly   391 INYGLKFSKTKFGQ----ALMDEMQMNSGGSS----PDSLRRMQGRVGAGGCNGMHVTTATNRFS 447
               |.:.:..:.|.    |.:.:..:|...:|    |..||.:.
 Worm   385 ---GSETTTPRTGSVSVTASVTQRTLNPNNNSPVFPPQRLRLLS--------------------- 425

  Fly   448 GLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNA 512
                                  |..:|::|....|...... ..|...::..|..|...|.....
 Worm   426 ----------------------LVQMDEALKQRCAADNLDL-FRKIAGHLKIISAHFHNQQMEGK 467

  Fly   513 EDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSLYDDTKAI 557
            ..::|..:::|:||:||.||:..|:....:.:..:|:|:||..::
 Worm   468 ITEEWQLMSLVIDRIFLILFLAVSMAANIMFVYNSPTLFDDRPSL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	102/232 (44%)
		LIC	47..544	CDD:273305	175/519 (34%)
lev-8	NP_509932.2	LIC	10..499	CDD:273305	182/547 (33%)
		Neur_chan_LBD	30..258	CDD:280998	100/227 (44%)
		Neur_chan_memb	268..497	CDD:280999	69/280 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920