Protein Alignment nAChRalpha2 and acr-5

DIOPT Version :10

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 144/526 - (27%)
• Similarity: 244/526 - (46%)
• Gaps: 73/526 - (13%)

  Fly    44 DAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKF 106
            |.:||.::||  :.|.:.:.|..:.|....|.|.:.|.|::|::...|.:..|||:...|.|...
 Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly   107 KWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVT-TMTKAIL---HYT-----GKVVWTPP 162
            .|:|.:||.:....||...||:||..|||:.:.|...| ::..|.|   |:.     .||....|
 Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQKKDGAKVQLMFP 232

  Fly   163 AIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEW 227
            ||:|.||.:|||:||:|:|.|.....|||:|...||...:|      :.|.:|...|    :.||
 Worm   233 AIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLS------STVNLGNMAR----NDEW 287

  Fly   228 DILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSG-- 290
            :::.....|.|:.:.||..|:..::.::.:|||.|:|.:||::|...|:.::|..|:.|..|.
 Worm   288 EVISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSE 352

  Fly   291 --EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNI----H 349
              ||:.|.|:.||:.::..|::...:||||..:||:..|.:..::::.:...:...:|.|    |
 Worm   353 RDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQKH 417

  Fly   350 YRKPSTHKMRPWIRS----FFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEM 410
            |.||.:.::|..|.:    |||...|..|:     ||.                |:||  ::.|
 Worm   418 YNKPISDRIRKLIYNPVVEFFILSPPTSLI-----DLW----------------TEFG--VISE- 458

  Fly   411 QMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTA-TNRFSGLVGALGGGLSTLSGYNGLPSVLSGLD 474
            |.:|....|..|:.|...        .|.|.| ...|.|.:.:....|.:...|....:.::...
 Worm   459 QRHSTHLDPLLLQHMDPI--------SHTTRADPQHFFGSISSQMCDLQSTYSYTARLATITRQY 515

  Fly   475 DSLSDVAARKKYPFELEKAIHNVMFI-QHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLV 538
            ...:.:.|.:|..:.:.........: :..|||:...     :|.|:|.|:||:.|.:| .....
 Worm   516 TQHAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSL-----EWEFLANVLDRILLTIF-CGFTF 574

  Fly   539 GTFVIL 544
            ..|:||
 Worm   575 AVFIIL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	73/229 (32%)
		LIC	47..544	CDD:455710	141/521 (27%)
		Cys-loop	169..183	CDD:349832	8/13 (62%)
acr-5	NP_001367477.1	LIC	104..581	CDD:455710	143/525 (27%)
		Neur_chan_LBD	104..321	CDD:460752	71/226 (31%)