DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and acr-5

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001367477.1	Gene:	acr-5 / 191596	WormBaseID:	WBGene00000044	Length:	598	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	144/526 - (27%)
Similarity:	244/526 - (46%)	Gaps:	73/526 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKF 106
            |.:||.::||  :.|.:.:.|..:.|....|.|.:.|.|::|::...|.:..|||:...|.|...
Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly   107 KWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVT-TMTKAIL---HYT-----GKVVWTPP 162
            .|:|.:||.:....||...||:||..|||:.:.|...| ::..|.|   |:.     .||....|
Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWNQKKDGAKVQLMFP 232

  Fly   163 AIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEW 227
            ||:|.||.:|||:||:|:|.|.....|||:|...||...:|      :.|.:|...|    :.||
Worm   233 AIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLS------STVNLGNMAR----NDEW 287

  Fly   228 DILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSG-- 290
            :::.....|.|:.:.||..|:..::.::.:|||.|:|.:||::|...|:.::|..|:.|..|.
Worm   288 EVISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSE 352

  Fly   291 --EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNI----H 349
              ||:.|.|:.||:.::..|::...:||||..:||:..|.:..::::.:...:...:|.|    |
Worm   353 RDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQKH 417

  Fly   350 YRKPSTHKMRPWIRS----FFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEM 410
            |.||.:.::|..|.:    |||...|..|:     ||.                |:||  ::.|
Worm   418 YNKPISDRIRKLIYNPVVEFFILSPPTSLI-----DLW----------------TEFG--VISE- 458

  Fly   411 QMNSGGSSPDSLRRMQGRVGAGGCNGMHVTTA-TNRFSGLVGALGGGLSTLSGYNGLPSVLSGLD 474
            |.:|....|..|:.|...        .|.|.| ...|.|.:.:....|.:...|....:.::...
Worm   459 QRHSTHLDPLLLQHMDPI--------SHTTRADPQHFFGSISSQMCDLQSTYSYTARLATITRQY 515

  Fly   475 DSLSDVAARKKYPFELEKAIHNVMFI-QHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLV 538
            ...:.:.|.:|..:.:.........: :..|||:...     :|.|:|.|:||:.|.:| .....
Worm   516 TQHAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSL-----EWEFLANVLDRILLTIF-CGFTF 574

  Fly   539 GTFVIL 544
            ..|:||
Worm   575 AVFIIL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	73/229 (32%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	141/521 (27%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	143/525 (27%)
acr-5	NP_001367477.1	Neur_chan_LBD	104..321	CDD:397192	71/226 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910