Protein Alignment nAChRalpha2 and acr-24

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001255865.1
• Gene: acr-24 / 190686
• WormBaseID: WBGene00013534
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 148/581 - (25%)
• Similarity: 257/581 - (44%)
• Gaps: 140/581 - (24%)

  Fly    47 RLYDDLLS--NYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWD 109
            ||..||..  .|:..:|||.|::....|...:.|.|::.:|.|.|.:..|||...:|.|....|:
 Worm    34 RLAKDLTDPRRYDSRVRPVMNHSKPTTVSFSMSLYQILSINEKQQNVDLNVWAIQKWNDDFLGWN 98

  Fly   110 PSEYGGVTELYVPSEHIWLPDIVLYNNA-----DGE----YVVTTMTKAILHY----TG-KVVWT 160
            |..||.:....:|.:.|||||..|||:.     :.|    .||||      :|    || :|.:.
 Worm    99 PYLYGMINTTILPFDAIWLPDTYLYNSVVMNREETERYINVVVTT------NYWKGETGAEVKFM 157

  Fly   161 PPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVE-IGIDLREYYPS 224
            .||::::||.:|:|:||:|||.|.:...|||           |.|:|.:.:.| ..:::..:.|:
 Worm   158 YPALYRTSCLLDIRFFPYDQQACKLTISSWT-----------SSKSDINYEPEHESVNMDNFLPN 211

  Fly   225 VEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADS 289
            .||.::....:|.|:.:.||.||:..:...:.:|||.|:|.|||:||...|:.::|..|:..|.:
 Worm   212 EEWVVVSFNIKRVEEKFVCCPEPWVLLEAVLVVRRKPLYYIVNLVIPTSVITLVAVTGFFTAAST 276

  Fly   290 G----EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHY 350
            .    ||::|.|..||:.::..:::||.:|::|..:||.|.:.|..:.::.:..:.|..|||:|.
 Worm   277 SSERREKLSLGIDSLLAMSILMMMVSEQMPTSSDFVPLFGIFYLSIIFIIFIGTLFTAFILNVHL 341

  Fly   351 RKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINY---GLKFSKT-----------K 401
            :|.....:.|.:...|..|:.:.|.||.|..||.......:.:   |.|.|||           .
 Worm   342 QKMYAKPVSPIVSYIFFGRIAQWLRMRPPTMLLELWNETGVTFGKEGQKNSKTIPKNHKMIPKVT 406

  Fly   402 FGQALMDEMQMNSG-GSSP-------------DSL---------RRMQGRVGAGGCNGMHVTTAT 443
            ...:.:..::.||| |.:|             |.:         ||:..::.:...||:.:
 Worm   407 SSSSGLHLLKSNSGSGRAPLAAPISARSYISMDDMKREAARRNWRRLVAKINSNKQNGVKI---- 467

  Fly   444 NRFSGLVGALGGG--------------LSTLSGYNGLP-------SVLSGL----DDSLSDVAAR 483
                     :|||              .|.:|..:|.|       |.:|..    |.::.:...:
 Worm   468 ---------VGGGERGQLRQANRKKMAPSAISVPHGEPGPLMLSASAISAFSVTGDSTILESKLK 523

  Fly   484 KKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVIL 544
            ::|..|                           |.::|.|:||:.|.:|.:.....|.:::
 Worm   524 RRYALE---------------------------WEYLASVLDRVLLIVFSLVVFAVTSIMI 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	73/232 (31%)
		LIC	47..544	CDD:273305	148/579 (26%)
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	72/230 (31%)
		Neur_chan_memb	255..>411	CDD:280999	41/155 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010