Protein Alignment nAChRalpha2 and pbo-5

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 407
• Identity: 111/407 - (27%)
• Similarity: 203/407 - (49%)
• Gaps: 45/407 - (11%)

  Fly    45 AKRLYDDLLSNYNRLIRPVSNNTDTVL-VKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKW 108
            :|||.:.|||.:|....|     |.:| |:..|.|..::.::...|.:|..::::..|.|....|
 Worm    67 SKRLTEYLLSRHNLNAPP-----DGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTW 126

  Fly   109 DPSEYGGVTELYVPSEHIWLPDIVLYNN------ADGEYVVTTMTKAILHYTGKVVWTPPAIFKS 167
            ||:.:||:|:.::|.:.||:|||:::|.      |..:.:......|.:||.|.:|.:.||:...
 Worm   127 DPALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTV 191

  Fly   168 SCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGV 232
            ||||::|:||.|.|.|.::..||.|..::|.| |....:          .|..|..:.||.:|.:
 Worm   192 SCEINIRHFPLDDQRCAIEIASWAYGQEKIRL-HAHTDH----------SLEHYKRNEEWHLLNL 245

  Fly   233 PAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVL----VFYLPADSGEKI 293
            ... .|||.....| ..::.|.|:|:|:.|||.|.|..|...:..:||:    .|....:..|:.
 Worm   246 NVS-EEKYEHEGVE-VSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERF 308

  Fly   294 ALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHY-----RKP 353
            .|.::.:|:..:..|::||.:|.:|..:|||..|.||.|::|.::.:.|.|::.:|.     .:|
 Worm   309 TLGVTAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGRYGDEP 373

  Fly   354 STHKMRPWIRSFFIKRLPKLLLMRV----PKDLLRDLAANKINYGLKFSK--TKFGQALMDEMQM 412
            |..    |:|.|.:|.:.:....|.    |::..:.:..::...|...:|  |:....::.|:.:
 Worm   374 SDF----WMRCFLLKPVFRTSNRRKYRMNPEEPTQVILVSEAKNGEVLTKKSTELNGTVVKEIML 434

  Fly   413 NSG-GSSPDSLRRMQGR 428
            :|. .:..:.:|:|..|
 Worm   435 SSRLEALEEYIRKMVNR 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	67/224 (30%)
		LIC	47..544	CDD:273305	110/405 (27%)
pbo-5	NP_001024240.1	Neur_chan_LBD	68..272	CDD:280998	67/221 (30%)
		Neur_chan_memb	306..>364	CDD:280999	18/57 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910