Protein Alignment nAChRalpha2 and lgc-1

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 377
• Identity: 93/377 - (24%)
• Similarity: 174/377 - (46%)
• Gaps: 44/377 - (11%)

  Fly    44 DAKRLYDDLLSNYNRLIRPV--------SNNTDTV-----LVKLGLRLSQLIDLNLKDQILTTNV 95
            |.|||:|||..:|:..:..:        .|.|.|:     .:||.:.:.:|:|:...::.:|...
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    96 WLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVV-----TTMTKAILHYTG 155
            ....||.|.:.||:|.||||::.:|||...||||::.:   ||...|.     .....|.::|.|
 Worm    80 DYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADAHEVKFFESDDAPRTAWINYNG 141

  Fly   156 KVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLRE 220
            ...:....:....|::||..||.|:..|.:.....||..|:..:|...:...|... ::|
 Worm   142 TTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIKSDMEPLPKPLS-QLG----- 200

  Fly   221 YYPSVEWDI--LGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVF 283
               :.||.:  :||..|.....:.....      |...:.|...||...:::|...|::||::..
 Worm   201 ---NGEWKVTYIGVAEEIGNGNFSAVQR------FVARIERNPGFYVTLVMVPAFFINFLSIIAL 256

  Fly   284 YLPADS-GEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLV--GLSVVITIII 345
            .|..:: ||||.:.::.:::.|...:::::.:|.|. .:|||..|::..:::|  .:.||:|:.:
 Worm   257 CLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTK-RIPLLAIYVIVGLVIVMASIGVVLTLPL 320

  Fly   346 LNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKF 397
            :..|.:|....|....:.:.|.|....|.:..|...:.:  .||.||:.:.|
 Worm   321 IRNHLKKRQKGKEEKPVETRFSKWFGWLTVEYVVMFVFQ--LANLINFIILF 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	59/238 (25%)
		LIC	47..544	CDD:273305	91/374 (24%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	68/269 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810