DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha2 and lgc-18

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_510029.3	Gene:	lgc-18 / 187977	WormBaseID:	WBGene00011360	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	334	Identity:	74/334 - (22%)
Similarity:	151/334 - (45%)	Gaps:	36/334 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RLYDDLLSNYNRLIRPVSNNTDTVL-------------VKLGLRLSQLIDLNLKDQILTTNVWLE 98
            :|..|:.:||:..:.||....|...             ..:.|...:|:::...::.::..:.:.
Worm    36 KLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYYLKLVEVIEPEEKVSVVLEMA 100

  Fly    99 HEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYN-NADGEYVVTTMTKAILHYTGKVVWTPP 162
            ..|.|.:..||.|.||.:..|::..:.:|.|.:.|:. |...::.........:..||....|..
Worm   101 EYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRMVCVENTGHTYTTLS 165

  Fly   163 AIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGI---DLREYYPS 224
            .....:|.:||..||:|.|||.::|....:...|:::  .||       :..||   .:.|...:
Worm   166 VKISLNCPLDVSMFPYDSQTCRIQFNMPLFFMQQVEM--FSQ-------IYEGILNSTVWEKMGN 221

  Fly   225 VEWDILGVPAERHEKYYPCCAEPYPDI---FFNITLRRKTLFYTVNLIIPCVGISYLSVL-VFYL 285
            .||::..:   .|........:...|:   .|.|.:||..::|...:|.|...|:.||:: ||..
Worm   222 SEWELANL---THSVELLSYGDGLGDMQLATFEIRIRRNPMYYIYMIIFPSFIINALSIIGVFLK 283

  Fly   286 PADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHY 350
            ..|...|:.:.::.:::.|....::::.||.|. ::||||.|::..:.::.::|.:||::..|
Worm   284 KTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLGIYIIVNLFIMIVAVGLTIVLAEI-- 345

  Fly   351 RKPSTHKMR 359
            :|.:..|:|
Worm   346 QKCAIPKLR 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	48/235 (20%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	74/334 (22%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	40/193 (21%)
		LGIC_TM_cation	259..>341	CDD:349853	21/82 (26%)
		TM1 helix	263..284	CDD:349853	7/20 (35%)
		TM2 helix	292..313	CDD:349853	1/20 (5%)
		TM3 helix	323..341	CDD:349853	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810