Protein Alignment nAChRalpha2 and lgc-16

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 373
• Identity: 75/373 - (20%)
• Similarity: 159/373 - (42%)
• Gaps: 83/373 - (22%)

  Fly    46 KRLYDDLLSNYNRLI----------RPVSNNTDTV---LVKLGLRLSQLIDLNLKDQILTTNVWL 97
            :.|.:||.:||:..|          .|:.:|..|:   ...:.|...:|:::....:.::..:.|
 Worm    37 ENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLEL 101

  Fly    98 EHEWQDHKFKWDPSEYGGVTELYVPSEHIWLP--------DIVLYNNADGEYVVTTMTKAILHYT 154
            ...|.|.:..|:.|.|..|:.::...|.:|.|        :|:.:.:.|...:....|..:..|.
 Worm   102 VERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDYL 166

  Fly   155 GKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLR 219
            ...|       .::|.:||..||||.|||.::|....::..|:.:                  |.
 Worm   167 SVRV-------SANCPMDVSRFPFDSQTCQIRFCLPIFNIRQVKI------------------LN 206

  Fly   220 EYYPSV------------EWDILGVPAERHEKYYPCCAEPYPDI---FFNITLRRKTLFYTVNLI 269
            |.|..:            ||.::.:.....:..|.   :.|.::   .|.||:||..|:|...::
 Worm   207 EIYEGILQEKIIKTMGNSEWKVVSLTNRVEQLKYD---DDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   270 IPCVGISYLSVL-VFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTML 333
            .|...|:.:|:: :|...||...|:.:.::.:::.|....::::.||.|. ::||||.|::..:|
 Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   334 LVGLSVVITIIILNIHYRKPSTHKMRPWI-------RSFFIKRLPKLL 374
            ::.:::.:.::|.          ::|.|.       :|:..::|...|
 Worm   333 IMIIAITVVVLIT----------ELRQWAVPRLKLKKSYMSRKLETFL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	50/252 (20%)
		LIC	47..544	CDD:273305	75/372 (20%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	40/209 (19%)
		LGIC_TM	261..>317	CDD:365787	12/55 (22%)
		TM1 helix	261..284	CDD:349850	5/22 (23%)
		TM2 helix	291..315	CDD:349850	2/23 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810