Protein Alignment nAChRalpha2 and lgc-14

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_510024.2
• Gene: lgc-14 / 187972
• WormBaseID: WBGene00011355
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 390
• Identity: 85/390 - (21%)
• Similarity: 159/390 - (40%)
• Gaps: 99/390 - (25%)

  Fly    51 DLLSNYNRLIRPVSNNTDTVLVKLG--------------LRLSQLIDLNLKDQILTTNVWLEHEW 101
            ||.:.|:..:.||.:..|. |..||              |...:|:::|...:.:...:.:...|
 Worm    40 DLFNGYDPTVSPVYSKIDP-LQPLGYDPDAPKRYNYSIMLYSLKLVEVNEPAEKVAVVMEIMEYW 103

  Fly   102 QDHKFKWDPSEYGGVTELYVPSEHIWLP--------DIVLYNNADGEYVVTTMTKAILHYTGKVV 158
            .|.:..|:.|.|..:...|....::|.|        ::|...:.|...|.......|..|....|
 Worm   104 YDIRLSWNASLYDDIDTFYTRQSNVWSPTLSAFGADELVDLRDPDFRMVCVNSNGYIYDYISVRV 168

  Fly   159 WTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGI---DLRE 220
                   .|||.::|..||||.|||.:||....::..:|.:         .|::.:|:   ||.|
 Worm   169 -------SSSCPMNVYKFPFDYQTCQIKFCLPIFNSVEIQI---------FNEIYVGVLMSDLWE 217

  Fly   221 YYPSVEWDILGVPAERHEKYYPCCAEPYPDIF-------FNITLRRKTLFYTVNLIIPCVGISYL 278
            ...:.||.:..: :.|.|..      .|.|.|       |.||::|..|:|...:|.|...|:.:
 Worm   218 TMGNSEWKLTNL-SNRVETL------QYNDGFGNLDLGIFEITIKRNPLYYIYMIIFPSFIINVV 275

  Fly   279 SVL-VFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSV-VI 341
            |:: ||...||...::.:.::.:::.|....::::.||.|. .:|:||.|::..:.::.::: ::
 Worm   276 SIIGVFLKGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-TIPMLGVYIIVNLAIMIIAIGIV 339

  Fly   342 TIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQAL 406
            |:|.           ::|.|:..|                             ||.::|||.:.|
 Worm   340 TMIT-----------ELRHWLAPF-----------------------------LKRNETKFSRKL 364

  Fly   407  406
             Worm   365  364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	56/243 (23%)
		LIC	47..544	CDD:273305	85/390 (22%)
lgc-14	NP_510024.2	LGIC_ECD_cation	75..257	CDD:349790	46/204 (23%)
		LGIC_TM	259..349	CDD:365787	21/101 (21%)
		TM1 helix	259..284	CDD:349850	8/24 (33%)
		TM2 helix	292..313	CDD:349850	1/20 (5%)
		TM3 helix	323..345	CDD:349850	3/32 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810