Protein Alignment nAChRalpha2 and lgc-13

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_510023.2
• Gene: lgc-13 / 187971
• WormBaseID: WBGene00011354
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 386
• Identity: 93/386 - (24%)
• Similarity: 169/386 - (43%)
• Gaps: 73/386 - (18%)

  Fly    28 LLLVLLLLCETVQANP-----------DAK-RLYDDLLSNYNRLIRPVSNNTDT----------- 69
            :||.|:|..:....:|           :|: .|..||..||.:.:.||....||
 Worm     6 ILLKLILSTDAFYYDPQLYVPKYRDYLEAQGNLTADLFKNYEKDVSPVYAWFDTSKPLGYDPDAP 70

  Fly    70 -----VLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLP 129
                 .|....|:   ||.:|..::.::..:.|...|.|.:..|:.|:|..||.::...|.||.|
 Worm    71 QRYNYTLFLYNLK---LIQVNEPEEQVSVVLELMEYWYDPRLSWNASDYKNVTAIFTRQEKIWSP 132

  Fly   130 --------DIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMK 186
                    :|:.:.:.|...|.......|..|....|       .::|.:||..||||.|||.::
 Worm   133 TLTPFGVNEIIDFRDQDFRLVCIDNLGMIYDYLSVRV-------SANCRMDVTKFPFDSQTCQIR 190

  Fly   187 FG--SWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYP 249
            |.  .::|    :::|..::..:..|    ...:.|...:.||:::.: ..|.:..      .|.
 Worm   191 FSLPIFSY----LEVKIYTELYEGIN----NYSMFEVMGNSEWELINL-TNRVDFL------TYN 240

  Fly   250 DIF------FNITLRRKTLFYTVNLIIPCVGISYLSVL-VFYLPADSGEKIALCISILLSQTMFF 307
            |.|      :.|.:.|..|:|...::.|...|:.:|:: ||...||...::.:.::.:::.|...
 Worm   241 DRFDVELAVYEIKIARNPLYYFYMIVFPSFVINSVSIVGVFIKGADKMSRLNVGLTNIMTMTFIL 305

  Fly   308 LLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIK 368
            .::|:.||.|. .:||||.|::..:|::.::::|..||..|  ||..|.|:|....||.:|
 Worm   306 GVMSDKIPRTG-NVPLLGIYIIVNLLIMLVAIIIVTIITEI--RKCVTPKLRKNTSSFNLK 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	56/251 (22%)
		LIC	47..544	CDD:273305	87/355 (25%)
lgc-13	NP_510023.2	LGIC_ECD_cation	74..257	CDD:349790	45/207 (22%)
		LGIC_TM	259..>335	CDD:365787	20/76 (26%)
		TM1 helix	259..284	CDD:349850	7/24 (29%)
		TM2 helix	292..313	CDD:349850	2/20 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810