Protein Alignment nAChRalpha2 and acr-20

DIOPT Version :9

• Sequence 1: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 155/579 - (26%)
• Similarity: 265/579 - (45%)
• Gaps: 107/579 - (18%)

  Fly    28 LLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILT 92
            :||:..|:..||.:  |...:.:.:|..||..:.|.......:.|...:.|.|:|.:|...|.|.
 Worm     9 VLLLHSLVLLTVSS--DQYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQIISVNEPQQFLM 71

  Fly    93 TNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNN---ADGEYVVTTMTKAILHYT 154
            .|.|:...|.|....|||.::|.|||:.:|...|||||..|||:   .|.|      .:.:||
 Worm    72 LNAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDE------NRRLLH-- 128

  Fly   155 GKVVWTP-----------PAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQID--LKHISQKN 206
            .||....           |.|:|.||.:::|:||||.|:|.:.|||||:|..:||  ..:.||..
 Worm   129 AKVTTLGEGNGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNESQAI 193

  Fly   207 DKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIP 271
            ...|.:|          :..|::|.....|||..|.||...|..:.|.:|::||.|:|.:|||||
 Worm   194 GTTNCIE----------NEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIP 248

  Fly   272 CVGISYLSVLVFYLPADSG----EKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTM 332
            ...|:::|::.|:..:...    |||.|.|:.|||.::...::|:.:||||..:||:|.:....:
 Worm   249 TSIITFISIIGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMI 313

  Fly   333 LLVGLSVVITIIILNIHYR-----KPSTHKMRPWIRSFFIKRLPKLLLMRVP------------- 379
            ||:..|.:.:.:::.:..:     .||.:.|.      ..:.:.:.:.|.:|
 Worm   314 LLISFSTICSSVVIYVQKQGNLGNPPSKNFMN------IARAVNRFIRMEMPLIMKQAYAQKARE 372

  Fly   380 KDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGG--CN-GMHVTT 441
            :.|.|.....|.:...:..|....|||..::|.:...|..:.:...:..:..||  |. ...||.
 Worm   373 EKLRRQQMGRKQSLWTRVYKLAREQALRKDVQTSQNSSKFNEVLTPEKLIDNGGKRCTINKDVTC 437

  Fly   442 ATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARK---------KYPFELEKA---- 493
            .::  ||:|..            |:|::.|..||  .||:..:         :.|..|.||
 Worm   438 ISD--SGIVAM------------GVPTLASEDDD--QDVSLLELETTPTPAMQRPTRLHKASTCG 486

  Fly   494 -IHNVMF--IQHHMQRQDEFNAEDQDWGFVAMVMDRL----FLWLFMIAS----LVGTF 541
             ..::||  |:..:..:...|..:.::.::|.:::|:    ||::|::.|    |:|.|
 Worm   487 SFDSMMFRQIEVPVSPRTARNLAEIEYDWLAALLERIFLITFLFIFVLTSIGINLIGFF 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	75/234 (32%)
		LIC	47..544	CDD:273305	149/560 (27%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	73/231 (32%)
		LGIC_TM_cation	239..>329	CDD:349853	29/89 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010