DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha2 and lgc-30

DIOPT Version :9

Sequence 1:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_500015.3	Gene:	lgc-30 / 186551	WormBaseID:	WBGene00019069	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	115/458 - (25%)
Similarity:	199/458 - (43%)	Gaps:	85/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VQANPDAK-----RLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLE 98
            |.|:|||.     ||...:.|:....| |:.:....:.|.:...|.|::||:.::.:.|.:.:|:
Worm    55 VIADPDADGDPHGRLATWIRSHARHHI-PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLD 118

  Fly    99 HEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADG---EYVVTTMTKAILHYTGKVVWT 160
            ..|.|...||.|..:||:..::||.:.||.|:..:|::..|   :|...  ..|.|||.|.|...
Worm   119 VHWNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPD--ASAELHYNGLVRMF 181

  Fly   161 PPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSV 225
            .....||.|.|:.:.||||.|||....|||.|..:.::|....|:          |.|.::|.:.
Worm   182 VSISSKSFCPINFKRFPFDSQTCSFSCGSWAYQSNIVNLVAAKQE----------IALEDFYDNQ 236

  Fly   226 EWDILGVPAERHE---KYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPA 287
            ||  |...|....   :......|.:..::..:.|:|::.:|..||:.|...:|.::|:.|:.|.
Worm   237 EW--LLTDARLFNGTTRNVSAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPI 299

  Fly   288 DS----GEKIALCISILLSQTMFFLLI-------SEIIP---STSLALPLLGKYLLFTMLLVGLS 338
            ::    ..|..|.|..|||.::..|::       .|.:|   .:...:||:|.|.:..:.:|.::
Worm   300 NATGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSDVPLMGIYYMTLICIVSIA 364

  Fly   339 VVITIIILNIH---YRKPSTHKMRPW-IRSFFIKRL-----PKLLLMRVPKDLL----------- 383
            ...:.|.:::.   .|.||...: || ||....|:|     ||  ..|..||..
Worm   365 TCTSSIFVHLEKFALRNPSWQSV-PWYIRWLAAKKLFCCYVPK--SFRYDKDAYSRNNNVQAISL 426

  Fly   384 -----RDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRR-------------MQGRVG 430
                 |::|.|.|...:.|::......|.|.::    |.|.:..::             ::.|:|
Worm   427 HSTPDRNVAKNLIPKEINFTEVNQDAPLHDVLE----GPSAEKTQKIDLIVSLLREIIHLKERIG 487

  Fly   431 AGG 433
            |.|
Worm   488 ASG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	62/229 (27%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	110/445 (25%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:367255	59/218 (27%)
		LGIC_TM_cation	274..>374	CDD:349853	23/99 (23%)
		TM1 helix	278..298	CDD:349853	6/19 (32%)
		TM2 helix	310..338	CDD:349853	7/27 (26%)
		TM3 helix	352..374	CDD:349853	3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810