DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha2 and lgc-31

DIOPT Version :9

Sequence 1:NP_524482.1 Gene:nAChRalpha2 / 42919 FlyBaseID:FBgn0000039 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001256671.1 Gene:lgc-31 / 184752 WormBaseID:WBGene00008997 Length:675 Species:Caenorhabditis elegans


Alignment Length:556 Identity:135/556 - (24%)
Similarity:236/556 - (42%) Gaps:100/556 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 PDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFK 107
            |...||:||||..|.:..|||::....:.|.:.:.|.|::.|:.....::.:...|..|:|...|
 Worm   126 PVTYRLHDDLLRYYRKGTRPVTHPKKVISVSMSVFLYQIVKLDAVKNTISLSGSFELYWEDEFLK 190

  Fly   108 WDPSEYGGVTELYVPSEHIWLPDIVLYN--NADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCE 170
            |:||.|.|..|:::.|..||:|:..||.  |.:....:.:.....::|||:|.:..|...:|.|:
 Worm   191 WNPSSYEGAEEIFLSSSDIWIPEFSLYYSLNFNDAVKLQSNNDVRVNYTGQVRYYIPFSSESLCK 255

  Fly   171 IDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAE 235
            :||::||||.|.|.:.||||.:..|.|.....||          .:.|.::|.:.||::     :
 Worm   256 LDVKFFPFDVQQCSLLFGSWAHSNDSIKYSLYSQ----------NLSLIDFYDNQEWEL-----D 305

  Fly   236 RHEK-------YYPCCAEP--YPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGE 291
            .|..       .|.....|  :..|...:.::|::.:|..||:||...|:.:||:.|:.|:.||.
 Worm   306 THNSSVHSDGFLYDYLDPPLFWEMIIITLVMKRQSFYYVFNLVIPSTMITLVSVIGFHTPSTSGR 370

  Fly   292 ----KIALCISILLSQTMFFLLISEIIPSTSL-----------ALPLLGKYLLFTMLLVGLSVVI 341
                |..|.|..|:|.::..|.|.|.:|..|:           .:||:|.|....:.::|:|.|.
 Worm   371 MRDAKFRLGIMTLMSMSVILLAIVEDMPKFSMGTNRRGRGSFSGIPLIGLYYFILLAIIGMSTVT 435

  Fly   342 TIIILNIHYRKPSTHKMR-PWIRSFF------------IKRLPKLLLMRVPKDLLRDLAANKINY 393
            |.:.  ::..:.|..||. ||...:.            :.|.....:.:.|.:.|  |:...:..
 Worm   436 TSMF--VYLERESRVKMNVPWYLKWLSFDISPSKIARKLSRYRPQAMSQPPSEHL--LSNGHVRS 496

  Fly   394 GLKFSKTKFGQALMDEMQMNSGGSSPDSLRRMQGRVGAGGCNG-----------MHVTTATNRFS 447
            |::........:|:..:.....|         .|..|.||.||           .|....|....
 Worm   497 GIRDKARGVAASLLSLLPRPGSG---------VGNGGPGGDNGNSPFHMQHLHAYHQDNPTPARE 552

  Fly   448 GLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQR---QDE 509
            .:...|     ::|.|:.: .:....:.:|.|:|.      .:.:...::..|:..|..   ||:
 Worm   553 SIRRRL-----SMSQYDNM-LIYQYYEQALEDIAN------GVSRMAGSIAEIRSEMMAFLPQDD 605

  Fly   510 FNAEDQDWGFVAMVMDRL-FLWLFMIASLVGTFVIL 544
            .|.:.|      .|:.|| .|.||...|::.|.:.|
 Worm   606 INTKWQ------TVIRRLEILSLFFYVSVLFTTMYL 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha2NP_524482.1 LGIC_ECD_nAChR_proto_alpha-like 44..263 CDD:349832 63/229 (28%)
LIC 47..544 CDD:273305 133/550 (24%)
lgc-31NP_001256671.1 TM_EphA1 <43..>79 CDD:391457
LGIC_ECD_cation 153..339 CDD:349790 52/200 (26%)
LGIC_TM_cation 341..>442 CDD:349853 30/102 (29%)
TM1 helix 345..365 CDD:349853 8/19 (42%)
Neur_chan_memb 347..634 CDD:367256 68/317 (21%)
TM2 helix 377..398 CDD:349853 7/20 (35%)
TM3 helix 420..442 CDD:349853 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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